The invention discloses a two-hand rubbing simulation mechanism which comprises a rack and two sets of rubbing components arranged on the rack. Each rubbing component comprises a gear, a connecting rod, a sliding block with the center hinged to the rack or a guide piece with a cylindrical outer surface, the centers of the guide pieces are fixed to the rack, sliding grooves extending in the length directions of the connecting rods are formed in the connecting rods, the sliding blocks or the guide pieces are arranged in the sliding grooves in an interference fit mode to guide the connecting rods, the two gears on the rubbing components are meshed, and when an external drive mechanism drives the gear on one rubbing component to rotate, the lower ends of the connecting rods of the rubbing components can generate the simulation movement similar to two-hand rubbing. The simulation mechanism achieves the complex plane movement simulating the two-hand rubbing through few parts, is extremely simple in structure, low in manufacturing cost and high in work reliability, can meet the needs of all kinds of corresponding products for the two-hand rubbing simulation mechanism with the extremely low manufacturing cost, and has good practicability.