The invention relates to the technical field of pharmaceutical preparations, in particular to moxifloxacin hydrochloride dispersible tablets and preparation method thereof. The dissolution problem of moxifloxacin hydrochloride can be significantly improved by adding a proper amount of potassium bicarbonate or sodium bicarbonate to a formula of the dispersible tablets. After moxifloxacin granules are coated with Eudragit E100, coatings of the granules never break due to environmental pH; accordingly, adverse bitterness of moxifloxacin can be covered effectively, and administration compliance of patients is improved. In addition, granules of the medicinal composition are dry, the coating drying process can be completed in a fluidized bed, and the medicinal composition is applicable to industrial production.