The invention discloses a whitening, acne removal and freckle removal cosmetology medicine which is prepared by the following raw materials in parts by weight: 2-5 parts of chloramphenicol injection, 5-7 parts of akafen powder, 14-16 parts of lincomycin hydrochloride gel and 6-8 parts of compound ketoconazole cream. The chloramphenicol injection, the akafen powder, the lincomycin hydrochloride gel and the compound ketoconazole cream are put into a container according to the weight parts, then are uniformly mixed and stirred and are finally bottled and packaged. The whitening, acne removal and freckle removal cosmetology medicine can effectively remove skin acnes and whelk and solve the problems of hyperpigmentation and the like which are caused by chloasma, freckles, physical machinery or chemical burn and is low in cost, easy to manufacture and convenient to use.