The present invention relates to interactive registration of 2D images with 3D volume data, and in particular relates to the registration of two 2D images with 3D volume data. In order to provide 2D/3D registration with a facilitated workflow for the user, an example of a method is provided comprising the steps of providing (110) 3D volume data (112) of an object, comprising a frame of reference; defining (114) a transformation plane (116) in relation to the 3D volume data perpendicular to the image plane of the first image; aligning the frame of reference with the second 2D image, wherein at least one alignment interaction value (128) is projected (130) on the transformation plane to determine (134) at least one transformed interaction value (132); and translating (136) the frame of reference with the at least one transformed interaction value.