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CN103402992A 制备4-羟基-2-氧代-2,5-二氢呋喃-3-羧酸酯的钠盐或钾盐的方法 有权

制备4-羟基-2-氧代-2,5-二氢呋喃-3-羧酸酯的钠盐或钾盐的方法
摘要：
制备式4-羟基-2-氧代-2，5-二氢呋喃-3-羧酸酯的钠盐或钾盐的方法，所述方法包括使丙二酸酯与氢氧化钾反应生成相应的式(III)的丙二酸酯钾盐，然后再与氯乙酸酯反应生成式(V)的化合物，随后进行环合反应，其中式(V)的化合物与式ZOR1的醇钠或醇钾反应，其中R1、R2、R3和K各自如说明书所定义。
摘要（英）：

A process for preparing sodium salts or potassium salts of 4-hydroxy-2-oxo-2,5-dihydrofuran-3-carboxylate, comprising the reaction of a malonic ester with potassium hydroxide to give the corresponding malonic ester potassium salt of the formula (III), which is then reacted further with a chloroacetic ester to give a compound of the formula (V), followed by a ring closure reaction in which the compound of the formula (V) is reacted with a sodium alkoxide or potassium alkoxide of the formula ZOR1, wherein R1, R2, R3 and K are each as defined in the description.

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