The invention belongs to the technical field of spirit brewing, and provides a production process of multi-grain Fenjiu, which aims at solving the problem of single-grain brewing. Brewing raw materials include sorghum, wheat, corns, rice and glutinous rice. The production process comprises a series of process steps of pulverizing and blending the raw materials and auxiliary materials, moisturizing and steaming the pulverized grains, adding water to the grains for casting, cool spreading the grains, putting yeast into the grains, fermenting the grains in a jar, blending the grains taken out of the jar with auxiliary materials, distilling the mixture in a steamer, re-fermenting the mixture in the jar, etc., thus obtaining the multi-grain Fenjiu. The Fenjiu has the advantages that the spirit body smells good with obvious compound grain fragrant, and is fresh, elegant, pure and soft in mouthfeel; the smell is compound and rich, and the mouthfeel is mellow and soft; by adopting multiple grain materials appropriate parameters of moisture, temperature and the like, the solid state Fenjiu fermentation rule of 'being slow at the beginning and at peak in the middle and slowly falling at last' can be achieved relatively perfectly, and as a result, the mouthfeel of the novel spirit is ensured to some extent; and under the condition that the special flavor is unaffected, the spirit body of the multi-grain brewed spirit is relatively high in purity degree, and the content of ethanal and n-amyl alcohol is reduced.