The invention discloses a nano-carrier particle controllable in drug release, which has a three-layer core-shell structure and comprises outer-layer mesoporous silica, an interlayer silica shell layer and an inner-layer gold nanorod; drug is loaded in the mesoporous silica; raman molecule is coated on the silica shell layer; the raman molecule is marked on the gold nanorod; the drug is connected on the mesoporous silica by a molecule containing a disulfide bond in a manner of a covalent bond, and the disulfide bond is cut off under the action of glutathione in a cell, so as to release the drug molecule. The invention also discloses a preparation method of the nano-carrier particle controllable in drug release. The nano-drug carrier particle and the preparation method can effectively avoid advance leakage of the drug and reduce the toxic and side effects of the drug, and simultaneously, SERS (surface enhanced raman scattering) signals are integrated in the nano-drug carrier particle, so that precise optical tracing on the nano-drug carrier particle is realized, great convenience is brought to the research on administration behavior, and can effectively improve the cancer chemotherapy efficiency.