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发明公开
CN102973954A 淀粉样蛋白成像作为抗淀粉样蛋白疗法的功效的替代标记物 无效 - 撤回

淀粉样蛋白成像作为抗淀粉样蛋白疗法的功效的替代标记物
摘要：
本发明的用于确定治疗淀粉样变性中治疗功效的方法包括向需要该确定的患者施用通式(I)或者通式(II)或者结构1-45的化合物并给患者成像。在所述成像后，向所述患者施用至少一种抗淀粉样蛋白剂。然后，向患者施用有效量的通式(I)或者通式(II)或者结构1-45的化合物并再次给患者成像。最后，将用抗淀粉样蛋白剂治疗前患者的淀粉样蛋白沉积基线水平与用抗淀粉样蛋白剂治疗后患者的淀粉样蛋白沉积水平进行比较。
摘要（英）：

The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or structures 1-45 and imaging the patient. After said imaging, at least one anti-amyloid agent is administered to said patient. Then, an effective amount of a compound of formula (I) or Formula (II) or structures 1-45 is administered to the patient and the patient is imaged again. Finally, baseline levels of amyloid deposition in the patient before treatment with the anti-amyloid agent are compared with levels of amyloid deposition in the patient following treatment with the anti-amyloid agent.

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