A device/system and a method for the treatment of enlarged prostate and other urologic abnormalities are presented. This system enables the simultaneous attachment of several interstitial coaguiative treatment probes as well as an ablative fiber to perform a combined treatment utilizing the intervention time and the time of the localized anesthesia effect in an optimal manner. The amount of tissue removed by the urologist by vaporization can be kept to a minimum, thanks to the (delayed) improvement of the achieved symptom scores resulting from the denaturalizing effect of the interstitial coaguiative fibers. In one preferred embodiment, two or more types of delivery systems are embedded in a single device for achieving optimal tissue ablation and coagulation effects including at least one non-laser source such as microwave energy, capable of producing radiation energy to coagulate tissue and at least one laser source capable of producing radiation to ablate tissue. In another preferred embodiment, device comprises two or more laser sources which emit at adjustable wavelengths controllable by physician according to ablative and coaguiative needs and tissue penetration needs depending on their effective absorption in different tissue components. Wavelengths ranges are chosen such that tissue absorption properties change sensibly with small variations of such wavelengths, based on a steep region of the absorption curve. Radiation may be applied in continuous, semi-continuous or pulsed wave, in different combinations. In another preferred embodiment, optical fiber has a central core for transmitting laser radiation, and a cladding layer about the core that may further transmit other laser radiation of a different or a same wavelength as the core.