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发明公开
CN102643349A 携带乙肝病毒抗原表位的重组嵌合蛋白及其制备 有权

携带乙肝病毒抗原表位的重组嵌合蛋白及其制备
摘要：
本发明提供一种携带乙肝病毒抗原表位的重组嵌合蛋白及其制备，具体是分别携带有乙肝病毒S82、C19、S125、S2[8]、S1[93]或C117抗原表位的重组嵌合蛋白，以及同时携带乙肝病毒S82,C19，S125，S2[8],S1[93]和C117抗原表位的重组嵌合蛋白，经免疫学WesternBlot检测，所述各个重组蛋白不仅具有VP6F蛋白的抗原反应性与免疫原性，还具有HBV抗原表位的抗原反应性和免疫原性，且不具有传染性，没有毒力返祖和肠套叠等副作用，对开发新一代RV/HBV重组嵌合疫苗及试剂具有重要价值。
摘要（英）：

The invention discloses a recombinant chimeric protein carrying a hepatitis B virus epitope and the preparation thereof, particularly a recombinant chimeric protein respectively carrying a hepatitis B virus S82, C19, S125, S2[8], S1[93] or C117 epitope, and a recombinant chimeric protein simultaneously carrying hepatitis B virus S82, C19, S125, S2[8], S1[93] and C117 epitopes, and through the immunology WesternBlot detection, each recombinant protein not only has the antigen reactivity and the immunogenicity of a VP6F protein, but also has the antigen reactivity and the immunogenicity of the HBV (hepatitis B virus) epitope, does not have infectivity and the side effects of virulence atavism, the intussusception and the like, and has important value for developing new generation RV (Rota Virus)/HBV recombinant chimeric vaccine and reagent.

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