The invention provides a self-clamping full-rotating cleaning device for a coating of a high pressure water pipeline. The cleaning device comprises a hydraulic clamping mechanism, an axial displacement mechanism, a circumferential rotating mechanism and a support, wherein, the support comprises a tail-end support, a lower crossbeam and a front-end support, and two ends of the lower crossbeam are connected with the front-end support and the tail-end support; the hydraulic clamping mechanism comprises hydraulic clamping oil cylinders arranged on the front-end support and the tail-end support; the axial displacement mechanism comprises main hydraulic oil cylinder arranged between the front-end support and the tail-end support; and the circumferential rotating mechanism comprises a drive unit, a drive fixed disk, a drive support, nozzle adjusting devices, nozzles, guide wheels, a bull gear and a guide rail, the drive support is connected with end covers of the front ends of the main hydraulic oils cylinders, the drive fixed disk, the guide wheels, the bull gear and the guide rail are arranged on the drive support, the drive unit is arranged at one side of the drive support deviated from the bull gear and is connected with a pinion through a transmission shaft, the pinion is engaged with the bull gear in a linkage manner, the nozzle adjusting devices are arranged at two sides of the lower end of the bull gear, and the nozzles are fixed on the nozzle adjusting devices and are used for efficiently cleaning the coating of the pipeline.