The invention provides a preparation process for a Gansu soft capsule. The preparation process comprises the following steps of: getting and crushing penthorum chinense, decocting and filtering the penthorum chinense, concentrating filtrate to form liquid extract, and adopting a macroporous resin column as a column of the liquid extract to obtain clean extract; drying the clean extract to obtain dry extract, and crushing the dry extract to obtain medicine powder; uniformly mixing the medicine powder, solvent and thickening agent to obtain a mixture A, adding natural polymer compound in water for swelling to obtain a mixture B, and mixing the mixture A and the mixture B to obtain a mixture C; uniformly mixing gelatin, plasticizing agent and opacifier in water to obtain a mixture D, and adding preservative and gelatinizing agent into the mixture D for sol to obtain a soft capsule material; and pelleting, forming, washing and drying content and the soft capsule material to obtain the Gansu soft capsule. In the invention, ineffective and harmful components in Traditional Chinese medicine raw materials are abandoned, so that the purity of medicine is improved, and dosage taken by a patient is reduced.