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CN102228475A 预防和/或治疗肝硬化的干细胞复合药物及其制备方法 无效 - 驳回 转让

预防和/或治疗肝硬化的干细胞复合药物及其制备方法
摘要：
本发明公开了一种预防和/或治疗肝硬化的干细胞复合药物及其制备方法。该预防和/或治疗肝纤维化和/或肝硬化的干细胞复合物，它的活性成分为离体的人脐带间充质干细胞和低抗凝肝素组成的组合物；所述低抗凝肝素的抗凝效价为(27-33)×103U/g；所述离体的人脐带间充质干细胞和所述低抗凝肝素的配比为106-108个人脐带间充质干细胞和(70-80)U低抗凝肝素。本发明的由人脐带间充质干细胞和低抗凝肝素组成的干细胞复合物可以显著缓解慢性肝病患者的临床症状，显著降低患者血清中谷丙转氨酶、透明质酸、IV型胶原和层粘连蛋白的含量。
摘要（英）：

The invention discloses a stem cell compound medicament for preventing and/or treating cirrhosis and a preparation method thereof. The active ingredients of the stem cell compound medicament for preventing and/or treating the cirrhosis are compositions consisting of invitro human umbilical cord mesenchymal stem cells and low anticoagulation heparins; the anticoagulation valence of the low anticoagulation heparin is (27-33)*10<3>U/g; and the invitro human umbilical cord mesenchymal stem cells and the low anticoagulation heparins are in a ratio of (10<6>-10<8>): human umbilical cord mesenchymal stem cells to (70-80)U low anticoagulation heparins. In the invention, the stem cell compound consisting of the human umbilical cord mesenchymal stem cells and the low anticoagulation heparins can significantly alleviate clinical symptoms of patients suffered from chronic liver diseases, and significantly reduce the content of glutamic-pyruvic transaminase, hyalyronic acid, IV-type collagen and laminin in blood serum of the patients.

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