Disclosed is a novel means for regulating an inflammatory reaction by regulating the signaling of an inflammatory response induced by non-homeostatic cell death. Specifically disclosed are: an anti-inflammatory agent comprising a substance capable of inhibiting the expression of mincle or the interaction between mincle and SAP130 or FcRgamma; a method for the screening of a substance capable of regulating an inflammatory reaction, which is characterized by comprising contacting mincle or a fragment thereof containing an extracellular domain with SAP130 in each of the presence and the absence of a substance to be tested and comparing the degrees of the interaction between mincle or the fragment thereof and SAP130 under these two conditions to each other; a method for detecting non-homeostatic cell death, which is characterized by comprising measuring the quantity of SAP130 in a sample collected from an animal to be tested; and others.