The invention discloses synthesis of adamantane sulfonyl chloride. The synthesis is characterized by being realized by the following steps of: (1) mixing chloroadamantane with sodium hydrosulfide in the molar ratio of (1-1.5):1 and preparing adamantane-based thiol through reaction by taking methanol as a solvent; and (2) mixing the adamantane-based thiol with water in the molar ratio of 1:(2-2.5), dripping an oxidant in an ice-water bath under a light shading condition, stirring for separating a greyish-white solid out along with reaction, removing the ice-water bath, continually dripping theoxidant, stopping introduction of the oxidant till the pH value is between 1 and 2, continually reacting for 20-30 minutes to obtain a greyish-white solid after the reaction, washing and drying the grayish-white solid to obtain the adamantine sulfony chloride. The method has the advantages that the synthesis of adamantane sulfony chloride with a stable structure and high yield is realized, small amount of acid and no byproducts are generated after the reaction, the operation is simple, the cost is low, and the method is suitable for mass production.