The invention provides a method for breeding a high-ammonia-nitrogen and high pH resistant species of a prawn, which can solve the problems of degraded quality, poor stress resistance and low breeding survival rate of prawn breeding existing in the prior art. Specifically, the new species with high stress resistance is screened by manually breeding the yellow sea No.1 fenneropenaeuschinensis with favorable growth characters as a basic group and adopting a combined breeding method of group breeding and family breeding through a high-ammonia-nitrogen and high pH stress test. The new high-stress resistance species screened by using the method is capable of aggregating and growing, has favorable characters of stress resistance and improves the high-ammonia-nitrogen and high pH resistance by 30 percent.