The invention discloses an antihypertension drug compound preparation. The compound preparation is mainly constituted by taking the mixture of 20-400 parts by weight of piperazine ferulate and 5-10 parts by weight of hydrochlorothiazide as medicinal components. The invention provides a compound antihypertension preparation which is convenient to take, safe to use and formed by the piperazine ferulate and the diuretic of hydrochlorothiazide. The compound antihypertension preparation can omnidirectionally control the blood pressure, namely the piperazine ferulate can block the blood pressure elevation effect of the ET while reduce systolic blood pressure; the hydrochlorothiazide can reduce diastolic blood pressure by reducing blood volume through diuretic effect, so that the invention has the most reasonable blood reduction effect.