The invention relates to a long-distance air-flotation linear guide rail unaffected by air pipe disturbance, comprises an air flotation shaft and at least two air flotation sleeves, wherein the air flotation sleeves are sleeved on the air flotation shaft and are both connected with an air storage sleeve in a sealing way; the air storage sleeve is connected with a guide bearing member which is in follow-up with a moving member; the long-distance air-flotation linear guide rail also comprises a long-distance linear guide rail which is used for providing support and guidance for long-distance motion, wherein a sliding block can be slidably arranged on the long-distance linear guide rail and fixedly connected with the air flotation shaft; an air storage cavity is arranged between the air storage sleeve and the air flotation shaft; and the shaft center of the air flotation shaft is provided with an air inlet channel which is connected with a compressed air inlet pipe and communicated with the air storage cavity; and the air storage cavity is provided with an air outlet which is communicated with air outlets of all air flotation sleeves through air pipes. The invention can effectively realize long distance, eliminate the influence of resistance generated by the motion of the sliding block due to bending of air pipes and is high in reliability and convenient to install, use and maintain.