The invention discloses a high pressure picosecond pulse generator, and relates to the structure of the high pressure picosecond pulse generator. The high pressure picosecond pulse generator mainly comprises a power supply system, a marx generator, a peaking switch, a super high-frequency cable, a bottom cutting switch, and a coaxial load. The high pressure picosecond pulse output by the high pressure picosecond pulse generator has the characteristics of adjustable amplitude, changeable pulse width, controllable repetition frequency, compact structure, simple installation, convenient adjustment, stable and reliable work and the like. The high pressure picosecond pulse generator can be widely applied to the industries of communication, radar, medical treatment, geophysical prospecting and the like, and is used as a high pressure picosecond pulse signal source with the known characteristics.