A method for tuning a digital compensation filter within a transmitter includes: obtaining at least one loop gain calibration result by performing loop gain calibration based upon signals of at least a portion of the transmitter, and obtaining at least one resistance-capacitance (RC) detection result by performing RC detection on the portion of the transmitter without individually measuring resistance values of resistors therein and capacitance values of capacitors therein, wherein the RC detection result corresponds to a detected value representing a product of a resistance value and a capacitance value, and the digital compensation filter includes a gain compensation module and an RC compensation module; and tuning the digital compensation filter by respectively inputting the loop gain calibration result and the RC detection result into the gain compensation module and the RC compensation module. An associated digital compensation filter and an associated calibration circuit are also provided. The invention has one advantage that the accurate loop parameter control can be provided, and the robustness to resist PVT mutation can be improved.