The invention relates to a Tegafur/LDHs nanometer hybrid and a preparation method thereof, and aims to provide a method for preparing a Tegafur/LDHs nanometer hybrid for slow release of Tegafur to improve potency and reduce the toxic or side effect of medicaments by taking LDHs as a carrier. LDHs is taken as a main body, the Tegafur is taken as an intercalation object, and the Tegafur is assembled between LDHs layers by a coprecipitation method or a structure reconstruction method to prepare the Tegafur/LDHs nanometer hybrid. The Tegafur/LDHs nanometer hybrid and the preparation method have the advantages that: the nanometer hybrid prepared by the two methods is large in medicament-loading capacity and has good slow-release effect; the adopted preparation method is simple and the condition is moderate; the structure, compositions and the release rate of the Tegafur/LDHs can be controlled by adjusting a synthetic method or synthesis conditions or changing factors such as concentration,the pH, temperature, aging time and the like in the synthetic process of the medicaments.