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CN101686956A 用环糊精增加氟苯尼考及结构相关的抗生素的溶解度的化合物和方法 无效 - 撤回

用环糊精增加氟苯尼考及结构相关的抗生素的溶解度的化合物和方法
摘要：
氟苯尼考(FFC)在水中的相对低的溶解度(1.3mg/mL)，限制了其在治疗猪和家禽的肺病的加药饮用水系统中的应用。现行的制剂采用高容量的有机溶剂，以在自动比例调节器混合箱系统中达到所需的13.5mg/mL的FFC浓度，而对于该领域的使用者而言存在现实的缺点。本发明涉及与天然和改性环糊精形成的复合物对FFC和相关结构的抗生素在水中溶解度的影响。此外，本发明涉及作为助溶剂的聚乙二醇(PEG-300)在FFC-环糊精系统中的作用，在混合箱系统中达到所需FFC剂量并避免高容量的有机溶剂。
摘要（英）：

The relatively low solubility of florfenicol (FFC) in water (1.3mg/mL) limits its use in medicated drinking water systems for treatment of pulmonary disease of swine and poultry. Current formulationsuse a high volume organic solvent to reach the required FFC concentration of 13.5mg/mL in an automated proportioner mixing tank system, with practical disadvantages for the users in the field. This invention relates to the effects of complex formation with natural and modified cyclodextrins on the aqueous solubility of FFC and antibiotics of related structure. Furthermore, this invention relates to the effects of polyethylene glycol (PEG-300) as a co-solvent in an FFC-cyclodextrin system to achieve the required FFC dose in the mixing tank system and to avoid high volumes of the organic solvent.

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