The invention relates to a mould making method with a conformal cooling pipe, aiming at solving the technical problems of three-dimensional curve setting of the existing mould cooling runner and the application of processing by laser melting and forming process. The technical scheme is as follows: a mould external contour shell with a design wall thickness and the conformal cooling pipe are manufactured by a laser melting and forming method, wherein the conformal cooling pipe is arranged in the mould external contour shell which is preheated; the gap formed between the mould cooling pipe and the mould external contour shell is casted and filled; and the mould external contour shell and the casted and filled part are subjected to whole surface finishing treatment. The method has the advantages that the mould manufacturing method has simple process, the mould manufacturing accuracy is high, the mould cooling pipe can be arranged at will according to design requirements, thus meeting thecooling requirement of the mould in the cooling process, improving the service life of the mould reducing the mould manufacturing cost and manufacturing period, and simultaneously being capable of changing the material of the mould external contour shell to meet the mould manufacturing with different requirements.