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CN101595127A 用于诱导脊椎动物发生免疫应答的、包含有涵盖了单种抗原AMA1的异质性的大量蛋白质变体的蛋白质组合物 失效 - 权利终止

用于诱导脊椎动物发生免疫应答的、包含有涵盖了单种抗原AMA1的异质性的大量蛋白质变体的蛋白质组合物
Abstract:
本发明涉及适用于诱导脊椎动物免疫应答的、包含单一抗原的2至10种蛋白质变体的蛋白质组合物，其中所述的单一抗原为疟原虫属物种的顶膜抗原1(PfAMA1或AMA1)。所述的抗原具有多个可变氨基酸位置，其中所述蛋白质变体的氨基酸序列以组合方式代表了各种氨基酸在所述的可变氨基酸位置处的发生频率，以及所述的可变氨基酸位置之间的关联，并且其中所述的发生频率在所述的单一抗原中至少为10％至20％，例如10％、11％、12％、13％……20％，并且其中所述的可变氨基酸位置之间至少75％的关联由蛋白质变体的组合来表示。
Abstract(English):

The present invention relates to a protein composition suitable for inducing an immune response in a vertebrate comprising 2 to 10 protein variants of a single antigen, which is the APICAL MEMBRANE ANTIGEN 1 (PfAMAl or AMAl) of a Plasmodium species. The antigen comprises a plurality of variable amino acid positions, wherein the amino acid sequences of said protein variants, in combination, represent both the frequency of occurrence of each amino acid at said variable amino acid positions and the linkage between the variable amino acid positions, and wherein said frequency of occurrence is at least between 10% to 20% such as 10%, 11%, 12%, 13%, ..., 20% in the single antigen, and wherein at least 75% of the linkages between the variable amino acid position is presented by the combination of protein variants .

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