The invention discloses an integrative water purification device for high and low muddy water. The device comprises a main body device, a medicament mixing and feeding system and an automatic control system, wherein the main body device has a straight cylinder structure, and comprises a clear water area, a lightweight suspension filter bed, a buffer area, a first reaction area, a second reaction area and a mud collecting area in turn from the top to bottom. The bottoms of the first reaction area and the second reaction area are provided with a high muddy water distributor and a low muddy waterdistributor respectively. The device adopts a two-point water distribution mode, high and low muddy water distribution systems are mutually independent and converted through the automatic control system, and the flow and reaction time of the raw water in the device are changed to adapt to water quality change and realize the compatibility of high and low muddy water treatment capabilities. The device organically combines caking flocculation and upward flow filter of the lightweight suspension filter bed, and can integrate flocculation, precipitation, filter and self cleaning of filter materials.