知搜-全球专利检索

  1. 登录
  2. 注册
发明公开
CN101548971A 木质素二氢黄酮醇在制备抑制单纯疱疹病毒药物中的应用 失效 - 权利终止

木质素二氢黄酮醇在制备抑制单纯疱疹病毒药物中的应用
摘要：
本发明涉及一个木质素二氢黄酮醇衍生物用于制备抑制单纯疱疹病毒药物的用途。具体而言，本发明涉及化合物(±)－2－[2，3－二氢－2－(4－羟基苯基)－3－羟甲基－1，4苯并二氧六环－5]－2，3－二氢－3，5，7－三羟基－4H－1－苯并吡喃－4－酮或其可药用盐在制备抑制由单纯疱疹病毒HSV－1引发的病毒感染和/或治疗口腔溃疡的药物的用途。该化合物由化学方法合成制备而得，经药理实验证明，该化合物对单纯疱疹病毒HSV－1有强效抑制作用，其半数抑制浓度IC50值为39.41微克/毫升。
摘要（英）：

The invention relates to application of lignin flavanonol in preparation of antiviral drugs, particularly, the invention relates to a chemical compound as formula (I), (+-)-2-[2,3-dihydro-2-(3,5-dimethoxy-4-hydroxy phenyl)-3-hydroxymethyl-1,4-benzodioxane-5]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyrone-4-ketone, or use of its medicinal salt used for preparing drugs for repressing virus infection caused by herpes simplex virus HSV-1 and/or drugs for curing oral ulcer. The chemical compound is prepared by chemical synthesis, pharmacological experiments shows that, the chemical compound has powerful inhibitory action to the herpes simplex virus HSV-1, and the half inhibitory concentration value IC[50] is 39.41 mg/mL.

公开/授权文献
0/0