The invention provides a production process for improving the bulk density of spiramycin. The process includes: under 30 to 100 DEG C, a spiramycin wet product acquired through crystallizing spiramycin water solution is placed in a closed container and forms a yellow block by being placed below 15 DEG C for an appropriate time period and changing the temperature in the process of spiramycin crystallization; the color turns to similar white after being placed for 0.5 to 3 hours under 20 to 35 DEG C; then the block is crushed into particles and goes through a 40-80 mesh sieve and the particles above 40 mesh undergo secondary rolling, granulation and sieving; the particles below 80 mesh are placed below 15 DEG C again and re-form the yellow block for repeated use; finally, the raw materials from 40 to 80 mesh are collected and dried below 80 DEG C for 3 to 6 hours until the water content meets the standard; the dried material is the spiramycin consistent with the bulk density requirement.