The invention discloses a collimator regulation system comprising a collimator comprising a collimating slit extended horizontally along the longitudinal direction; a first adjusting device connected to one longitudinal end of the collimator and capable of moving vertically along the direction vertical to the collimating slit approximately; and a second adjusting device connected to the other one longitudinal end of the collimator and capable of moving vertically along the direction vertical to the collimating slit approximately. In addition, the invention discloses a method for adjusting the collimator system. According to the technical scheme, the automatic adjustment of the collimator position can be implemented, thereby avoiding the trouble and the difficulty of the manual adjustment. Moreover, because of providing with two independent adjusting devices, not only the adjustments of the upper and lower positions of the collimator can be implemented, but also the inclined adjustment of the collimator position can be implemented. Thereby the adjusting process can be simplified, and the ideal position of the collimating slit of the collimator can be determined rapidly and accurately.