The invention relates to a thermal transfer printing method. The method comprises: making a transfer printing membrane after printing adhered to the surface of a substrate, and transferring at least partial patterns on the transfer printing membrane to the substrate through thermoprint of the transfer printing membrane, wherein the substrate is organic glass; and the thermoprint temperature is between 190 and 239 DEG C, and the thermoprint time does not exceed 25 seconds. The method successfully realizes application of the thermal transfer printing method to the organic glass, initiates a novel field of organic glass processing of, and greatly widens the application field of the organic glass.