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Invention Publication
CN101384617A 抗原和佐剂的多聚体复合物 有权 转让

抗原和佐剂的多聚体复合物
Abstract:
本发明涉及包含C4bp结构域和抗原的产物，所述C4bp结构域为非哺乳动物来源的C4bp结构域，特别是SEQ ID NO：1、SEQ ID NO：23或SEQ IDNO：37的C4bp结构域，或者是其变体。在理想状态下产物是融合蛋白的形式。也对SEQ ID NO：1和SEQ ID NO：23的鸡C4bp结构域进行了描述。抗原包括单体抗原，如疟疾和流感抗原。C4bp结构域提供给抗原的多聚体复合物或其混合物的装配。这些复合物可以用作疫苗。
Abstract(English):

The invention relates to a product which comprises a C4bp domain of a non-mammalian origin, particularly SEQ ID NO:1, SEQ ID NO:23 or SEQ ID NO:37, or a variant thereof, and an antigen. The product is desirably in the form of a fusion protein. The chicken C4bp domain of SEQ ID NO:1 and SEQ ID NO:23 is also described. Antigens include monomeric antigens such as malarial and influenza antigens. TheC4bp domain provides for assembly of multimeric complexes of the antigen, or mixtures thereof. The complexes are useful as vaccines.

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