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CN101322681B 一种制备蒽环类抗肿瘤抗生素的纳米胶束制剂的方法 有权 转让

一种制备蒽环类抗肿瘤抗生素的纳米胶束制剂的方法
摘要：
本发明提供了一种制备蒽环类抗肿瘤抗生素的纳米胶束制剂的方法，包括：(1)将蒽环类抗肿瘤抗生素在水或药用缓冲盐溶液中溶解；(2)将聚乙二醇衍生化磷脂在水或药用缓冲盐溶液中溶解；(3)将(1)和(2)混合，在25℃-60℃下水化，得到蒽环类抗肿瘤抗生素的纳米胶束。与现有技术的方法相比，本发明的方法简单易操作，不含有有机溶剂，不需要复杂的大型仪器设备，适合于工业生产。
摘要（英）：

The invention provides a method for preparing a nano micelle preparation of anthracycline antitumor antibiotics, including the following steps: (1) dissolving anthracycline antitumor antibiotics in water or medicinal buffer salt solution; (2) dissolving polyethylene glycol-phospholipid in water or medicinal buffer salt solution; (3) mixing the solution in step (1) and the solution in step (2) andhydrating the mixture at 25 DEG C to 60 DEG C to obtain the nano micelle of anthracycline antitumor antibiotics. Compared with the prior art, the method of the invention is simple and easy to operate, does not need complex large-scale instruments, and is suitable for industrial production, and the obtained nano micelle preparation does not contain nano organic solvent.

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