The invention provides a preparation method of total glucosides of paeony granules, which is prepared by dry granulation after mixing raw materials of total glucosides of paeony and pharmaceutical excipients; the mix ratio of the raw materials of total glucosides of paeony and pharmaceutical excipients is 1: 0.001 to 1: 25, a dry type granulator is adopted for granulation, the appropriate granules are prepared by regulating extrusion force, extrusion frequency conversion, feeding frequency conversion and side sealing pressure of the dry type granulator, and the scope of parameters are set as follows: the extrusion force is 0 to 15kg, the extrusion frequency conversion is 20 to 50Hz, the feeding frequency conversion is 20 to 45Hz and the side sealing pressure is 5 to 20kg; the total glucosides of paeony granules prepared by the invention have good flowability and can reduce the moisture absorbance property, be used for preparing various drug formulations and also be prepared into granules, hard capsules, soft capsules, tablets and such formulations by direct preparation or after being added appropriate excipients.