The invention relates to a specific mould powder of crystallization mould of high strength steel containing V, Nb, Ti of slab costing and a production process thereof. The mould powder comprises pre-melted raw materials, flux materials, alkalinity adjustment materials and carbonaceous materials, and the weight percentages are that: 78-85 percent of pre-melted raw materials, 5-12 percent of flux materials, 5-10 percent of alkalinity adjustment materials and 2-6 percent carbonaceous materials; the production process of the invention is: various qualified materials are crushed to appropriate size and sent into a furnace; water quenching is carried out to the material taken out from the furnace; then gasification is done and sent into a pre-melted material storehouse. The qualified pre-meltedraw materials, flux materials, alkalinity adjustment materials and carbonaceous materials are made to be gasified and sent into the material storehouse to be burdened, then sent into a mixer; a semi-finished product is made to be tested, if qualified, sent into a ball mill to be dry ground and into a water mill to be finely ground, so as to make slurry; the next steps are material extraction, spraying, product testing, packaging and storing. The production of the invention has the advantages that product has little slag strip; the spreading property of the crystallization mould is good; reaction inside the crystallization mould is active with small flame.