The invention relates to an industrial method for preparing 3- amino- 2, 2- bimethyl propionamide, which is a segment in high pressure protein proenzyme inhibitor. The invention takes normal and cheapcyanoacetamide as raw material, alkalyating two nethyls, catalytic hydrogenating or adding reducant agent and getting 3- amnio- 2, 2- bimethyl propionamide. The chenmical reaction is shown in the graph. The invention solves problems of difficulty of getting raw material, low productivity and long process line, needs no column chromatography and purification, avoids toxic potassium cyanide and realizes large scale production.