The invention discloses a method of preparing a Ni-based monocrystal high-temperature alloy through the crystallon method, comprising: firstly a crystallon which is provided with a certain crystal orientation is cut directionally on the Ni-based monocrystal high-temperature alloy; the crystallon is extended into a parts wax pattern; and ceramics castable refractory is smeared on the outside of thecrystallon and the parts wax pattern; then a ceramics shuttering provided with the crystallon is manufactured via dewaxing and burning; and the Ni-based monocrystal high-temperature alloy material isteemed, shaped and manufactured by making use of the ceramics shuttering in a monocrystal furnace. The invention relates to a monocrystal preparation technology which can accurately control crystalorientation of the monocrystal and fine texture to manufacture the high quality Ni-based monocrystal high-temperature alloy material.