公开(公告)号：US20240116879A1

公开(公告)日：2024-04-11

申请号：US18039917

申请日：2021-12-03

Applicant: Duke University ,  Case Western Reserve University ,  Rutgers, The State University of New Jersey

Inventor： Amanda Hargrove ,  Blanton Tolbert ,  Gary Brewer ,  Neeraj Narendra Patwardhan ,  Mei-Ling Li

IPC: C07D241/34 ,  A61P31/14

CPC classification number: C07D241/34 ,  A61P31/14

Abstract: The present disclosure describes, in part, compositions comprising derivatives and methods of using the same in prevention or treatment of viral infections in a subject.

公开(公告)号：US20190389816A1

公开(公告)日：2019-12-26

申请号：US16554990

申请日：2019-08-29

Applicant: Biotron Limited

Inventor： Peter William Gage ,  Gary Dinneen Ewart ,  Lauren Elizabeth Wilson ,  Wayne Best ,  Anita Premkumar

IPC: C07D241/34 ,  C07C279/22 ,  A61K31/55 ,  A61K31/4965 ,  A61K45/06 ,  A61K31/165

Abstract: The invention relates to compounds having antiviral and methods utilizing the compounds to treat viral infections.

公开(公告)号：US20130178482A1

公开(公告)日：2013-07-11

申请号：US13533911

申请日：2012-06-26

Applicant: MICHAEL R. JOHNSON

Inventor： MICHAEL R. JOHNSON

IPC: A61K31/4965 ,  A61K45/06 ,  C07D241/34

CPC classification number: C07D241/26 ,  A61K31/4965 ,  A61K45/06 ,  C07D239/48 ,  C07D241/34

Abstract: The present invention relates to the compound of the formula: or pharmaceutically acceptable salts thereof, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, acute and chronic bronchitis, cystic fibrosis, emphysema, and pneumonia.

Abstract translation: 本发明涉及下式的化合物或其药学上可接受的盐，以及含有该化合物的组合物，其制备方法和用于促进粘膜表面水合和治疗疾病的治疗方法 包括慢性阻塞性肺疾病（COPD），哮喘，支气管扩张，急性和慢性支气管炎，囊性纤维化，肺气肿和肺炎。

公开(公告)号：US20050032864A1

公开(公告)日：2005-02-10

申请号：US10917221

申请日：2004-08-12

Applicant: Vidya Lohray ,  Braj Lohray ,  Rao Paraselli ,  Ranga Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Sarma Pakala

Inventor： Vidya Lohray ,  Braj Lohray ,  Rao Paraselli ,  Ranga Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Sarma Pakala

IPC: C07D239/36 ,  C07D239/46 ,  C07D239/88 ,  C07D241/34 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  A61K31/4178 ,  C07D43/02

CPC classification number: C07D239/36 ,  C07D239/47 ,  C07D239/88 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

Abstract: The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

Abstract translation: 本发明涉及新的抗糖尿病化合物，其互变异构形式，其衍生物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 本发明特别涉及通式（I）的新的唑来二酮衍生物及其药学上可接受的盐，药学上可接受的溶剂合物和含有它们的药物组合物。

公开(公告)号：US3507865A

公开(公告)日：1970-04-21

申请号：US3507865D

申请日：1967-04-27

Applicant: MERCK & CO INC

Inventor： JONES JAMES H ,  CRAGOE EDWARD J JR

IPC: C07D241/24 ,  C07D241/26 ,  C07D241/30 ,  C07D241/34 ,  C07D401/12 ,  C07D405/12 ,  C07D51/76

CPC classification number: C07D241/24 ,  C07D241/26 ,  C07D401/12 ,  C07D405/12 ,  Y10S514/869

公开(公告)号：US10752597B2

公开(公告)日：2020-08-25

申请号：US15446877

申请日：2017-03-01

Applicant: Parion Sciences, Inc.

Inventor： Michael R. Johnson

IPC: A61K31/4965 ,  C07D241/26 ,  C07D239/48 ,  A61K45/06 ,  C07D241/34

Abstract: The present invention relates to the compound of the formula: or pharmaceutically acceptable salts thereof, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, acute and chronic bronchitis, cystic fibrosis, emphysema, and pneumonia.

公开(公告)号：US10526292B2

公开(公告)日：2020-01-07

申请号：US15849454

申请日：2017-12-20

Applicant: Parion Sciences, Inc.

Inventor： Michael Ross Johnson ,  William Robert Thelin ,  Richard C. Boucher

IPC: A61K31/497 ,  A61K31/4965 ,  A61K45/06 ,  C07D241/32 ,  C07D241/34

Abstract: Sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.

公开(公告)号：US10472332B2

公开(公告)日：2019-11-12

申请号：US15602526

申请日：2017-05-23

Applicant: Biotron Limited

Inventor： Peter William Gage ,  Gary Dinneen Ewart ,  Lauren Elizabeth Wilson ,  Wayne Best ,  Anita Premkumar

IPC: C07D241/34 ,  A61K31/165 ,  A61K45/06 ,  A61K31/15 ,  A61K31/381 ,  A61K31/4406 ,  A61K31/47 ,  A61K31/4965 ,  A61K31/55 ,  C07C279/22

Abstract: The invention relates to compounds having antiviral and methods utilizing the compounds to treat viral infections.

公开(公告)号：US20150313909A1

公开(公告)日：2015-11-05

申请号：US14615616

申请日：2015-02-06

Applicant: Biotron Limited

Inventor： Peter William Gage ,  Gary Dinneen Ewart ,  Lauren Elizabeth Wilson ,  Wayne Best ,  Anita Premkumar

IPC: A61K31/55 ,  A61K31/4965 ,  A61K45/06 ,  C07D241/34 ,  A61K31/165 ,  C07C279/22

CPC classification number: C07D241/34 ,  A61K31/15 ,  A61K31/165 ,  A61K31/381 ,  A61K31/4406 ,  A61K31/47 ,  A61K31/4965 ,  A61K31/55 ,  A61K45/06 ,  C07C279/22

Abstract: The invention relates to compounds having antiviral activity and methods utilizing the compounds to treat viral infections.

Abstract translation: 本发明涉及具有抗病毒活性的化合物和利用该化合物治疗病毒感染的方法。

公开(公告)号：US3527759A

公开(公告)日：1970-09-08

申请号：US3527759D

申请日：1967-09-29

Applicant: MERCK & CO INC

Inventor： SHEPARD KENNETH L

IPC: C07D241/26 ,  C07D241/30 ,  C07D241/34 ,  C07D51/76

CPC classification number: C07D241/26