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203 条记录 (耗时 0.031 秒)

    Amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1- (protected hydroxy)-propane salts and methods of making the same
    1.
    发明授权
    Amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1- (protected hydroxy)-propane salts and methods of making the same 有权

    公开(公告)号：US12122735B2

    公开(公告)日：2024-10-22

    申请号：US17987469

    申请日：2022-11-15

    申请人： Geron Corporation

    发明人： Jennifer Elizabeth Albaneze-Walker

    IPC分类号： C07C235/00 ,  C07C231/12

    CPC分类号： C07C235/00 ,  C07C231/12

    摘要： Aspects of the disclosure includes methods for preparing an amorphous solid composition of a fatty acid metal salt. In practicing the subject methods according to certain embodiments, a succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane organic salt is contacted with a metal base to produce a succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt; and the succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt is precipitated in a solvent to produce an amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt composition. An amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane lithium salt is also provided.

    Amorphous Solid Succinylated 3-(Fatty Acid Amido)-2-Hydroxy-1-(Protected Hydroxy)-Propane Salts and Methods of Making the Same
    2.
    发明公开
    Amorphous Solid Succinylated 3-(Fatty Acid Amido)-2-Hydroxy-1-(Protected Hydroxy)-Propane Salts and Methods of Making the Same 审中-公开

    公开(公告)号：US20230192597A1

    公开(公告)日：2023-06-22

    申请号：US17987469

    申请日：2022-11-15

    申请人： Geron Corporation

    发明人： Jennifer Elizabeth Albaneze-Walker

    IPC分类号： C07C235/00 ,  C07C231/12

    CPC分类号： C07C235/00 ,  C07C231/12

    摘要： Aspects of the disclosure includes methods for preparing an amorphous solid composition of a fatty acid metal salt. In practicing the subject methods according to certain embodiments, a succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane organic salt is contacted with a metal base to produce a succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt; and the succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt is precipitated in a solvent to produce an amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt composition. An amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane lithium salt is also provided.

    Agomelatine hydrobromide hydrate and preparation thereof
    6.
    发明授权
    Agomelatine hydrobromide hydrate and preparation thereof 有权
    氢溴酸阿莫拉坦及其制备方法

    公开(公告)号：US08729132B2

    公开(公告)日：2014-05-20

    申请号：US13635087

    申请日：2011-03-17

    申请人： Hanbin Shan ,  Zhedong Yuan ,  Xueyan Zhu ,  Peng Zhang ,  Hongjuan Pan ,  Xiong Yu

    发明人： Hanbin Shan ,  Zhedong Yuan ,  Xueyan Zhu ,  Peng Zhang ,  Hongjuan Pan ,  Xiong Yu

    IPC分类号： A01N37/18 ,  A61K31/16 ,  C07C233/00 ,  C07C235/00 ,  C07C237/00 ,  C07C239/00

    CPC分类号： C07C233/18 ,  A61K31/165

    摘要： The present invention relates to an agomelatine hydrobromide hydrate of formula I wherein X is Br, preparation and use thereof, and to pharmaceutical compositions containing it. The agomelatine hydrobromide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps.

    摘要翻译： 本发明涉及其中X是Br的式I的氢溴酸阿尔美拉酸水合物，其制备和用途以及含有它的药物组合物。 通过本发明方法获得的氢溴酸氢溴酸水合物与阿魏酸相比具有显着增加的溶解度，因此更适用于制备药物制剂。 此外，该产品具有更高的稳定性和纯度。 使用本方法，可以通过简单的工艺获得高纯度的产品，没有任何复杂的步骤。