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公开(公告)号：US10138191B2
公开(公告)日：2018-11-27
申请号：US15951765
申请日：2018-04-12
Applicant: SHIN-ETSU CHEMICAL CO., LTD.
Inventor： Yuki Miyake , Takeshi Kinsho , Tatsuya Fujii
IPC: C07C45/42 , C07C41/52 , C07C21/00 , C07C17/263 , C07C21/04
Abstract: Provided are a 1-halo-6,9-pentadecadiene useful as an intermediate having a skipped diene skeleton and a method for producing (7Z,10Z)-7,10-hexadecadienal. More specifically, provided are a method for producing (7Z,10Z)-7,10-hexadecadienal including steps of subjecting a Grignard reagent formed from a (6Z,9Z)-1-halo-6,9-pentadecadiene to a nucleophilic substitution reaction with an orthoformate ester to obtain a (7Z,10Z)-1,1-dialkoxy-7,10-hexadecadiene; and hydrolyzing the (7Z,10Z)-1,1-dialkoxy-7,10-hexadecadiene in the absence of an oxidation reaction to obtain the (7Z,10Z)-7,10-hexadecadienal; and the like.
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公开(公告)号：US09079818B2
公开(公告)日：2015-07-14
申请号：US12249958
申请日：2008-10-12
Applicant: Sudip Mukhopadhyay , Cheryl L. Bortz , Barbara A. Light , Cheryl L. Cantlon , Robert C. Johnson
Inventor： Sudip Mukhopadhyay , Cheryl L. Bortz , Barbara A. Light , Cheryl L. Cantlon , Robert C. Johnson
Abstract: Disclosed is a process for the synthesis of fluorinated olefins, and in particularly preferred embodiments tetrafluorinated olefins having F on an unsaturated, non-terminal carbon, such as 2,3,3,3-tetrafluoropropene. The preferred processes of the present invention in accordance with one embodiment generally comprise: (a) reacting a compound of formula (I) X1X2 (I) with a compound of formula (II) CX1X2X3CX1═CX1X2 (II) to produce a reaction product comprising a compound of formula (III) CF3CHX1CH2X2 (III), and (b) exposing said compound of formula (III) to reaction conditions effective to convert said compound of formula (III) to a compound of formula (IV) CF3CZ═CH2 (IV) wherein X1, X2, and X3 are each independently selected from the group consisting of hydrogen, chlorine, bromine, fluorine and iodine, provided that X1 and X2 in formula (I) are not both hydrogen and Z is Cl, I, Br, or F.
Abstract translation: 公开了用于合成氟化烯烃的方法，特别优选的实施方案中，在不饱和的非末端碳上具有F的四氟化烯烃如2,3,3,3-四氟丙烯。 根据一个实施方案的本发明的优选方法通常包括：（a）使式（I）X1X2（I）化合物与式（II）化合物CX1X2X3CX1 = CX1X2（II）反应以产生反应产物，其包含 式（III）化合物，CF 3 CHX 1 CH 2 X 2（III）的化合物，和（b）将式（III）化合物暴露于有效将式（III）化合物转化成式（IV）化合物的反应条件：CF 3 CZ = CH 2 ）其中X1，X2和X3各自独立地选自氢，氯，溴，氟和碘，条件是式（I）中的X1和X2不同时为氢，Z为Cl，I，Br， 或F.
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公开(公告)号：US09000243B2
公开(公告)日：2015-04-07
申请号：US13089635
申请日：2011-04-19
Applicant: John G Pendergast, Jr. , William S. White , Anthony R. Avilla , Thomas U Luebbe
Inventor： John G Pendergast, Jr. , William S. White , Anthony R. Avilla , Thomas U Luebbe
CPC classification number: C07C17/383 , B01D3/141 , C07C19/03 , C07C19/041 , C07C19/04
Abstract: The present invention relates to a process for separating chlorinated methanes utilizing a dividing wall column. Processes and manufacturing assemblies for generating chlorinated methanes are also provided, as are processes for producing products utilizing the chlorinated methanes produced and/or separated utilizing the present process(es) and/or assemblies.
Abstract translation: 本发明涉及利用分隔壁塔分离氯化甲烷的方法。 还提供了用于产生氯化甲烷的方法和制造组件，以及利用本方法和/或组件生产和/或分离的氯化甲烷生产产物的方法。
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4.发明授权Compositions comprising a dehalogenase substrate and a contrast agent and methods of use 有权包含脱卤酶底物和造影剂的组合物和使用方法
公开(公告)号：US08921620B2
公开(公告)日：2014-12-30
申请号：US13450217
申请日：2012-04-18
Applicant: Keith V. Wood , Dieter Klaubert , Georgyi V. Los , Robert F. Bulleit , Mark McDougall , Chad Zimprich
Inventor： Keith V. Wood , Dieter Klaubert , Georgyi V. Los , Robert F. Bulleit , Mark McDougall , Chad Zimprich
CPC classification number: C12Q1/34 , C07C217/08 , C07C271/16 , C07D209/48 , C07D233/64 , C07D311/78 , C07D311/82 , C07D405/06 , C07D493/10 , C07D495/04 , C07F5/022 , C12N9/14 , C12N9/86 , C12Y308/01005 , G01N33/5005 , G01N33/58 , Y10S436/80
Abstract: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.
Abstract translation: 提供任选融合到感兴趣的蛋白质的突变体水解酶。 突变体水解酶能够与相应的非突变（野生型）水解酶的底物形成键，其比野生型水解酶和底物之间形成的键更稳定。 还提供了包含一个或多个官能团的水解酶的底物，以及使用本发明的突变体水解酶和底物的方法。 还提供能够与底物形成稳定结合的融合蛋白和表达融合蛋白的细胞。
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公开(公告)号：US08618339B2
公开(公告)日：2013-12-31
申请号：US12110890
申请日：2008-04-28
Applicant: Ekaterina N. Swearingen
Inventor： Ekaterina N. Swearingen
CPC classification number: C07C17/354 , C07C21/18
Abstract: Disclosed is a method for the synthesis of fluorinated alkenes comprising contacting a fluorinated alkyne of the formula R1 C≡C R2, wherein R1 and R2 are independently selected from CF3, C2F5, C3F7, and C4F9, in a pressure vessel, with a Lindlar catalyst, with substantially one molar equivalent of hydrogen, to make the corresponding cis-alkene of formula R1 C≡C R2 with high selectivity, wherein said hydrogen is added in portions over a period of time, so as to produce an initial pressure in the pressure in the vessel of no more than about 100 psi.
Abstract translation: 公开了一种合成氟化烯烃的方法，包括使式R1 C = C R2的氟化炔，其中R 1和R 2独立地选自CF 3，C 2 F 5，C 3 F 7和C 4 F 9，在压力容器中与Lindlar催化剂 ，具有基本上1摩尔当量的氢气，以高选择性制备式R1 C = C R2的相应顺式烯烃，其中所述氢气在一段时间内分批加入，以便产生压力的初始压力 在容器中不超过约100psi。
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6.发明授权Compositions comprising a dehalogenase substrate and a fluorescent label and methods of use 有权包含脱卤酶底物和荧光标记的组合物和使用方法
公开(公告)号：US08257939B2
公开(公告)日：2012-09-04
申请号：US12975020
申请日：2010-12-21
Applicant: Keith V. Wood , Georgyi V. Los , Robert F. Bulleit , Dieter Klaubert , Mark McDougall , Chad Zimprich
Inventor： Keith V. Wood , Georgyi V. Los , Robert F. Bulleit , Dieter Klaubert , Mark McDougall , Chad Zimprich
CPC classification number: C12Q1/34 , C07C217/08 , C07C271/16 , C07D209/48 , C07D233/64 , C07D311/78 , C07D311/82 , C07D405/06 , C07D493/10 , C07D495/04 , C07F5/022 , C12N9/14 , C12N9/86 , C12Y308/01005 , G01N33/5005 , G01N33/58 , Y10S436/80
Abstract: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.
Abstract translation: 提供任选融合到感兴趣的蛋白质的突变体水解酶。 突变体水解酶能够与相应的非突变（野生型）水解酶的底物形成键，其比野生型水解酶和底物之间形成的键更稳定。 还提供了包含一个或多个官能团的水解酶的底物，以及使用本发明的突变体水解酶和底物的方法。 还提供能够与底物形成稳定结合的融合蛋白和表达融合蛋白的细胞。
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公开(公告)号：US08252965B2
公开(公告)日：2012-08-28
申请号：US12540252
申请日：2009-08-12
Applicant: Daniel C. Merkel , Hsueh Sung Tung , Konstantin A. Pokrovski
Inventor： Daniel C. Merkel , Hsueh Sung Tung , Konstantin A. Pokrovski
IPC: C07C21/00
CPC classification number: C07C17/392 , C07C17/087 , C07C17/25 , C07C17/38 , C07C21/18 , C07C19/10
Abstract: The invention provides a method for separating halocarbons. In particular, a method for separating 2-chloro-1,1,1,2-tetrafluoropropane (HCFC-244bb) from 2-chloro-3,3,3-trifluoropropene (HCFO-1233xf) based on differences in melting points of these compounds. More particularly the invention pertains to a method for separating HCFC-244bb from HCFO-1233xf which are useful as intermediates in the production of 2,3,3,3-tetrafluoropropene (HFO-1234yf).
Abstract translation: 本发明提供一种分离卤代烃的方法。 特别地，基于这些的熔点的差异，从2-氯-3,3,3-三氟丙烯（HCFO-1233xf）中分离出2-氯-1,1,1,2-四氟丙烷（HCFC-244bb）的方法 化合物。 更具体地说，本发明涉及从HCFO-1233xf中分离HCFC-244bb的方法，其可用作生产2,3,3,3-四氟丙烯（HFO-1234yf）中的中间体。
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公开(公告)号：US07902410B2
公开(公告)日：2011-03-08
申请号：US11588671
申请日：2006-10-27
Applicant: Michael Van Der Puy , George R. Cook , Peter H. Scheidle , Kevin D. Uhrich
Inventor： Michael Van Der Puy , George R. Cook , Peter H. Scheidle , Kevin D. Uhrich
CPC classification number: C07C17/354 , C07C19/08 , C07C19/10
Abstract: A process for the production of fluorinated alkanes by contacting a feed stream containing a fluorinated olefin and a reducing agent, preferably with a first amount of catalyst to produce a fluorinated alkane, at a first conversion level, wherein a first effluent stream contains unreacted fluorinated olefin and reducing agent; and contacting the first effluent stream under conditions effective to produce a higher level of conversion than said conversion level.
Abstract translation: 通过使包含氟化烯烃和还原剂的进料流，优选与第一量的催化剂接触以产生氟化烷烃，以第一转化水平接触生产氟化烷烃的方法，其中第一流出物流含有未反应的氟化烯烃 和还原剂; 以及在有效地产生比所述转化水平更高水平的转化率的条件下接触第一流出物流。
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公开(公告)号：US20080063585A1
公开(公告)日：2008-03-13
申请号：US11931031
申请日：2007-10-31
Applicant: Richard Smalley , Daniel Colbert , Hongjie Dai , Jie Liu , Andrew Rinzler , Jason Hafner , Kenneth Smith , Ting Guo , Pavel Nikolaev , Andreas Thess
Inventor： Richard Smalley , Daniel Colbert , Hongjie Dai , Jie Liu , Andrew Rinzler , Jason Hafner , Kenneth Smith , Ting Guo , Pavel Nikolaev , Andreas Thess
IPC: C01B31/00 , C07C21/00 , C07C211/00 , C07C221/00 , C07C321/00 , C07C33/00 , C07K5/06 , C07K5/08 , C07K5/10 , C07K7/06
CPC classification number: D01F9/12 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C01B32/152 , C01B32/162 , C01B2202/02 , D01F9/127 , G11C13/025 , G11C2213/16 , G11C2213/71
Abstract: This invention relates generally to a fullerene nanotube composition. The fullerene nanotubes may be in the form of a felt, such as a bucky paper. Optionally, the fullerene nanotubes may be derivatized with one or more functional groups. Devices employing the fullerene nanotubes of this invention are also disclosed.
Abstract translation: 本发明一般涉及富勒烯纳米管组合物。 富勒烯纳米管可以是毡的形式，例如巴克纸。 任选地，富勒烯纳米管可以用一个或多个官能团衍生化。 还公开了使用本发明的富勒烯纳米管的装置。
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10.发明授权Catalytic method for the production of fluoroalkylenes from chlorofluorohydrocarbons 有权用于从氯氟烃生产氟代亚烷基的催化方法
公开(公告)号：US07135601B2
公开(公告)日：2006-11-14
申请号：US11091201
申请日：2005-03-28
Applicant: Sudip Mukhopadhyay , HsuehSung Tung
Inventor： Sudip Mukhopadhyay , HsuehSung Tung
IPC: C07C21/00
Abstract: A process for producing a producing a product of the formula: R—CF═CHR1 wherein R is F or CF3 and R1 is F when R is F and is H when R is CF3 by reacting a reactant of the formula: CF3—R2 wherein R2 is selected from and wherein R3 is H, F or Cl and R4 is H or Cl, in the presence of a suitable catalyst, with a reducing agent selected from methane, methyl chloride and mixtures thereof, in a gas phase reaction.
Abstract translation: 一种生产下式的产物的方法：<？in-line-formula description =“In-line formula”end =“lead”？> R-CF-CHR <1> 当R为F时，R为F或CF 3，R 1为F， 通过使下式的反应物反应，当R为CF 3时为H，其中：<？in-line-formula description =“In-Line Formulas”end =“lead”？> CF 3 < ＆lt;＆lt;＆lt;＆lt;＆lt;线内公式描述=“在线公式”end =“tail”？>其中R 2选自并且其中 R 3是H，F或Cl，R 4是H或Cl，在合适的催化剂存在下，与选自甲烷，氯甲烷和混合物的还原剂 在气相反应中。
