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64 条记录 (耗时 0.02 秒)

    Antiviral nucleoside reverse transcriptase inhibitor
    2.
    发明授权
    Antiviral nucleoside reverse transcriptase inhibitor 有权

    公开(公告)号：US11447512B2

    公开(公告)日：2022-09-20

    申请号：US16955482

    申请日：2018-12-06

    申请人： Shenzhen TargetRx, Inc.

    发明人： Yihan Wang ,  Jiuyang Zhao

    IPC分类号： A61K31/675 ,  C07F9/6561 ,  A61P31/20 ,  A61P31/18

    摘要： An antiviral nucleoside reverse transcriptase inhibitor compound as shown in formula (I), and a pharmaceutically acceptable salt, a stereoisomer, a solvate, a hydrate, a crystal form or an isotopic derivative of the compound. A preparation method therefor, a pharmaceutical composition thereof, and a use thereof in the preparation of a drug for treating and/or preventing viral infectious diseases, such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV).

    (Hetero)arylamide compound for inhibiting protein kinase activity
    3.
    发明授权
    (Hetero)arylamide compound for inhibiting protein kinase activity 有权

    公开(公告)号：US11319317B2

    公开(公告)日：2022-05-03

    申请号：US17098675

    申请日：2020-11-16

    申请人： Shenzhen TargetRx, Inc.

    发明人： Yihan Wang ,  Jiuyang Zhao ,  Yixin Ai

    IPC分类号： C07D417/14 ,  A61P35/00 ,  C07D401/14

    摘要： Provided are a (hetero)arylamide compound as shown in formula (I) having an inhibitory effect on protein kinase activity, a pharmaceutically acceptable salt, a stereoisomer, a solvate or hydrate thereof, a pharmaceutical composition including the compound or a derivative thereof, and a method for preparing the compound. The compound can be used as an irreversible inhibitor for protein kinase, for preparing a plurality of drugs including an anti-tumour drug.

    DIANILINOPYRIMIDINE COMPOUND FOR INHIBITING KINASE ACTIVITY
    4.
    发明申请
    DIANILINOPYRIMIDINE COMPOUND FOR INHIBITING KINASE ACTIVITY 有权

    公开(公告)号：US20210087213A1

    公开(公告)日：2021-03-25

    申请号：US16954246

    申请日：2018-12-12

    申请人： Shenzhen TargetRx, Inc.

    发明人： Yihan Wang ,  Huanyin Li

    IPC分类号： C07F9/6558 ,  C07F9/6512

    摘要： Disclosed are a dianilinopyrimidine compound having an inhibitory effect on protein tyrosine kinase, pharmaceutically acceptable salts, crystal forms, prodrugs, metabolites, hydrates, solvates, stereoisomers or isotopic derivatives thereof, a pharmaceutical composition containing these compounds, as well as preparation and use of these compounds. The compound has a structure as represented by formula (I), and may be used for treating ALK-mediated cancer-related symptoms, such as non-small cell lung cancer, breast cancer, nerve tumors, esophagus cancer, soft tissue cancer, lymphoma, or leukemia.

    Substituted heteroaryl compound, composition containing same, and application thereof
    5.
    发明授权
    Substituted heteroaryl compound, composition containing same, and application thereof 有权

    公开(公告)号：US10479767B2

    公开(公告)日：2019-11-19

    申请号：US16079880

    申请日：2016-12-13

    申请人： Shenzhen TargetRx, Inc.

    发明人： Yihan Wang ,  Xingye Ren

    IPC分类号： C07D217/24 ,  A61K31/472 ,  C07D217/26 ,  C07B59/00 ,  A61P7/06

    摘要： Provided in the present invention are a substituted heteroaryl compound, a composition containing same, and an application thereof, the present invention disclosing a heteroaryl compound of the formula (I), or a crystalline form, a pharmaceutically acceptable salt, a prodrug, a stereoisomer, a hydrate, or a solvent compound thereof. The substituted heteroaryl compound and the composition containing same set forth in the present invention can be used for regulating hypoxia inducible factor (HIF) and/or endogenous erythropoietin (EPO), simultaneously having better pharmacokinetic parameter characteristics and being able to improve the drug concentration of the compound in animal bodies, in order to improve the curative effect and safety of the drug.

    Alkynyl (hetero) aromatic ring compounds used for inhibiting protein kinase activity
    8.
    发明授权
    Alkynyl (hetero) aromatic ring compounds used for inhibiting protein kinase activity 有权

    公开(公告)号：US11746110B2

    公开(公告)日：2023-09-05

    申请号：US17260787

    申请日：2019-07-16

    申请人： Shenzhen TargetRx, Inc.

    发明人： Yihan Wang ,  Qingfeng Xing ,  Yixin Ai

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： Disclosed are alkynyl (hetero) aromatic ring compounds that inhibit protein tyrosine kinases, pharmaceutical compositions comprising same, preparations therefor and uses thereof. Specifically, disclosed are an alkynyl (hetero) aromatic ring compound represented by formula (I), and a pharmaceutically acceptable salt, a stereoisomer, a solvate, a hydrate, a crystal form, a prodrug or an isotope variant thereof. The disclosed compounds may be used in the treatment and/or prevention of diseases associated with protein tyrosine kinase, such as in preventing tumors.