Epi-fluoresence confocal optical analyte sensor

    公开(公告)号:US09874520B1

    公开(公告)日:2018-01-23

    申请号:US14972233

    申请日:2015-12-17

    Applicant: MOCON, INC.

    Inventor: Daniel W. Mayer

    Abstract: An optical sensor effective for (i) exciting an analyte-sensitive fluorophore, exposed to an unknown concentration of the analyte for which the fluorophore is sensitive, with radiant energy from an excitation source, (ii) measuring the extent to which luminescence of the excited fluorophore is quenched by presence of the analyte, (iii) ascertaining the concentration of analyte to which the fluorophore is exposed from such measurement, and (iv) reporting the ascertained concentration. The sensor is preferably an epi-fluroescence confocal optical detector, and preferably performs step (ii) by employing a summing amplifier.

    Analytical instrument and method for evaluating microbial contamination of an object
    3.
    发明授权
    Analytical instrument and method for evaluating microbial contamination of an object 有权
    用于评估物体微生物污染的分析仪器和方法

    公开(公告)号:US08563265B2

    公开(公告)日:2013-10-22

    申请号:US13450025

    申请日:2012-04-18

    Abstract: An instrument and method for ascertaining a viable aerobic microbe count at to employing a two-point calibration curve of tthreshold to TVC for each type of sample. One point on the calibration curve is the x-intercept value (i.e., an estimated or experimental value for the logarithm of the minimum viable aerobic microbe count at commencement of testing (to) in a sample effective for causing the sample to reach tThreshold substantially instantaneously upon commencement of incubation). The other point is ascertained experimentally from a sample having a smaller known viable aerobic microbe count at to.

    Abstract translation: 一种用于确定有活力的有氧微生物计数的仪器和方法,用于对每种样品采用TVC的tthreshold的两点校准曲线。 校准曲线上的一点是x截距值(即,对于有效使样品达到t阈值基本上瞬时的测试开始时(至)的最小可行有氧微生物计数的对数的估计或实验值 孵化开始后)。 另一点是从具有较小的已知可行有氧微生物计数的样品实验确定。

    LUMINESCENCE LIFETIME BASED ANALYTE SENSING INSTRUMENTS AND CALIBRATION TECHNIQUE
    4.
    发明申请
    LUMINESCENCE LIFETIME BASED ANALYTE SENSING INSTRUMENTS AND CALIBRATION TECHNIQUE 审中-公开
    基于LuminécenceLIFETIME的分析仪感测仪器和校准技术

    公开(公告)号:US20130005047A1

    公开(公告)日:2013-01-03

    申请号:US13581818

    申请日:2011-03-10

    CPC classification number: G01N21/6408 G01N21/274 Y10T436/209163

    Abstract: A method of calibrating a luminescence lifetime sensing instrument 20 and of interrogating a target-analyte long-decay luminescence probe 120 includes measuring and reporting luminescence lifetime of the probe 120 employing excitation radiation filtered to remove emission radiation, or a starting time tstart delayed by a predetermined decay delay time, or delayed by a predetermined growth delay time, or an ending time comprising the time at which luminescence intensity has decayed or risen a predetermined percentage.

    Abstract translation: 校准发光寿命感测仪器20和询问目标分析物长衰减发光探针120的方法包括使用经滤波以去除发射辐射的激发辐射来测量和报告探针120的发光寿命,或者延迟开始时间tstart 预定衰减延迟时间,或延迟预定生长延迟时间,或包括发光强度衰减或上升预定百分比的时间的结束时间。

    Valve system for a coulometric analyte sensing instrument
    6.
    发明授权
    Valve system for a coulometric analyte sensing instrument 有权
    用于库仑分析物传感仪器的阀门系统

    公开(公告)号:US08074683B1

    公开(公告)日:2011-12-13

    申请号:US12114497

    申请日:2008-05-02

    Abstract: A valve system that includes (i) first and second longitudinally facing members defining a gap therebetween in fluid communication with transversely offset first and second orifices through the members, (ii) a primary biasing means longitudinally biasing the members away from one another, (iii) an elastic element positioned within the gap between the first and second orifices, and (iv) a repositioning means for longitudinally repositioning one of the members towards the other member against the bias of the primary biasing means for adjusting the longitudinal height of the gap. The members can be repositioned between (a) a first position wherein the elastic element does not seal the gap so as to allow fluid flow from the first orifice to the second orifice through the gap, and (b) a second position wherein the elastic element is compressed between the members and seals the gap so as to prevent fluid flow from the first orifice to the second orifice through the gap.

    Abstract translation: 一种阀系统,其包括(i)第一和第二纵向对置的构件,其间形成有间隙,其间通过所述构件与横向偏移的第一和第二孔流体连通,(ii)主要偏压装置纵向地将构件彼此偏置地偏置(iii )定位在所述第一和第二孔之间的间隙内的弹性元件,以及(iv)重新定位装置,用于克服所述主偏压装置的偏压纵向地将所述构件中的一个朝向另一个构件定位,以调整所述间隙的纵向高度。 构件可以在(a)第一位置和第二位置之间重新定位,其中弹性元件不密封间隙,以便允许流体通过间隙从第一孔流向第二孔,以及(b)第二位置,其中弹性元件 被压缩在构件之间并密封间隙,以便防止流体从第一孔口流过第二孔口。

    System and method for generating a gas sample of known and adjustable relative humidity
    7.
    发明授权
    System and method for generating a gas sample of known and adjustable relative humidity 有权
    用于产生已知和可调节相对湿度的气体样品的系统和方法

    公开(公告)号:US07908936B2

    公开(公告)日:2011-03-22

    申请号:US12406603

    申请日:2009-03-18

    Inventor: Daniel W. Mayer

    CPC classification number: G01M3/007

    Abstract: A system and method for providing a destination point with a gas having a selectable known humidity. A gas having an initial relative humidity is alternately directed in accordance with a duty cycle along a wet path effective for humidifying the gas to provide a wet gas, and a dry path effective for either maintaining the initial relative humidity of the gas or dehumidifying the gas to provide a dry gas. The wet and dry gas is blended to produce a blended gas having a selected relative humidity based upon the selected duty cycle.

    Abstract translation: 一种用于向目标点提供具有可选择的已知湿度的气体的系统和方法。 具有初始相对湿度的气体根据沿着湿路径的占空比交替地引导,该湿路径有效地用于加湿气体以提供湿气,以及干燥路径对于保持气体的初始相对湿度或对气体进行除湿 提供干燥气体。 混合湿和干燥气体以产生基于所选占空比的具有选定相对湿度的混合气体。

    PHOTOIONIZATION DETECTOR HAVING IMPROVED GAIN AND REDUCED HUMIDITY SENSITIVITY

    公开(公告)号:US20240295529A1

    公开(公告)日:2024-09-05

    申请号:US18478046

    申请日:2023-09-29

    Applicant: Mocon, Inc.

    CPC classification number: G01N27/66 G01N33/0047

    Abstract: A photoionization detector comprised of a gas discharge lamp that ionizes molecules of interest to create ionized molecules and electrons and a sensor having at least one opening for UV light to pass through and electrically conductive patterns on at least one of the top and bottom surfaces of the plate, including at least a negative electrical potential pattern and an electron collecting electrode pattern. The ionized molecules are collectable by a bias electrode and electrons are collectable by a collector electrode. The negative electrical potential pattern includes a linear portion and a polarization plate. The electron collecting electrode pattern includes a wire suspended across the at least one opening and a linear portion on the surface opposite the wire. The electrically conductive patterns can further include a grounded potential conductive pattern having a first portion on the top surface and a second portion on the bottom surface.

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