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    Magnetic resonance imaging contrast system
    1.
    发明授权
    Magnetic resonance imaging contrast system 失效
    磁共振成像对比系统

    公开(公告)号：US06924150B1

    公开(公告)日：2005-08-02

    申请号：US10124203

    申请日：2002-04-17

    Applicant: Xiao Dong Xiang ,  Gerald F. Dionne ,  Haitao Yang

    Inventor： Xiao Dong Xiang ,  Gerald F. Dionne ,  Haitao Yang

    IPC: G01N24/00 ,  G01N24/10 ,  A61B5/055 ,  A61B8/00 ,  G01N25/18 ,  G01R33/00 ,  G01V3/00

    CPC classification number: G01N24/10 ,  G01N24/006 ,  Y10T436/24

    Abstract: A method for improving the magnetic resonance imaging contrast of a selected portion of a sample. A selected ferrimagnetic constituent is associated with the sample portion, by molecular or biological attachment or by some other means, so that the sample portion is distinguished from other adjacent portions of the sample that do not have the selected ferrimagnetic constituent associated therewith. Alternatively, the sample portion is suspected, but not yet confirmed, to have the selected ferrimagnetic constituent associated with it. Ferromagnetic resonance imaging is performed on the sample portion, and at least one resonance frequency ω0 of the sample portion is provided. At least one material parameter of the sample portion is measured at or near the frequency ω0, with enhanced imaging contrast relative to adjacent portions of the sample that do not have the selected ferrimagnetic constituent in association. Alternatively, the measured value is compared with a corresponding reference value for the selected ferrimagnetic constituent. If (and only if) the measured and corresponding reference values substantially agree, the selected ferrimagnetic constituent is present in association with the selected sample portion. Other parameters of the selected ferrimagnetic consituent can also be measured.

    Abstract translation: 一种用于改善所选部分样品的磁共振成像对比度的方法。 选择的亚铁磁性成分通过分子或生物附着或通过某种其他方式与样品部分相关联，使得样品部分与样品中没有与其相关联的选择的亚铁磁性成分的其它相邻部分区分开。 或者，怀疑但尚未确认样品部分具有与其相关联的所选择的亚铁磁性成分。 对样品部分进行铁磁共振成像，并且提供样品部分的至少一个共振频率ω0。 样品部分的至少一个材料参数在频率ω0处或附近被测量，相对于没有关联的选择的亚铁磁性成分的样品的相邻部分，具有增强的成像对比度。 或者，将测量值与所选择的亚铁磁性成分的相应参考值进行比较。 如果（且仅当）测量的和相应的参考值基本一致，则所选择的亚铁磁成分与选择的样品部分相关联地存在。 也可以测量所选铁氧体成分的其它参数。

    Spatially resolved spin resonance detection
    2.
    发明授权
    Spatially resolved spin resonance detection 有权
    空间分辨的自旋共振检测

    公开(公告)号：US06693426B1

    公开(公告)日：2004-02-17

    申请号：US10071563

    申请日：2002-02-09

    Applicant: Xiao Dong Xiang ,  Gang Wang ,  Haitao Yang ,  Gerald F. Dionne

    Inventor： Xiao Dong Xiang ,  Gang Wang ,  Haitao Yang ,  Gerald F. Dionne

    IPC: G01V300

    CPC classification number: G01N24/10 ,  G01N24/006 ,  Y10T436/24

    Abstract: Methods for spatially resolve spin resonance detection in a sample of material, with a resolution as small as 0.5 &mgr;m-1 mm. In one embodiment, a coupler having at least one pair of degenerate orthogonal modes provides an evanescent input signal along one coupler axis to the sample, to which a magnetic field is applied, and senses a spin interaction signal along another coupler axis. In another embodiment, an evanescent input signal is applied to the sample along one of two identical transmission line resonators, and a difference of the two resonator signals provides a spin interaction signal. In another embodiment, a polarized laser beam provides an evanescent input signal to the sample, and the spin interaction signal is sensed according to a second beam polarization direction. Certain ferromagnetic or ferrimagnetic molecules, such as YIG, can be used to tag selected chemical and biological molecules, using spatially resolved spin resonance detection for interrogation.

    Abstract translation: 在材料样品中空间分辨自旋共振检测的方法，分辨率小至0.5 mum-1 mm。 在一个实施例中，具有至少一对简并正交模式的耦合器提供沿着一个耦合器轴线向被施加磁场的样本的消逝输入信号，并且沿另一个耦合器轴线感测自旋相互作用信号。 在另一个实施例中，沿着两个相同的传输线谐振器中的一个将消逝的输入信号施加到样本，并且两个谐振器信号的差提供自旋相互作用信号。 在另一个实施例中，偏振激光束向样本提供消逝的输入信号，并且根据第二光束偏振方向感测自旋相互作用信号。 某些铁磁或亚铁磁分子，如YIG，可用于标记选定的化学和生物分子，使用空间分辨的自旋共振检测进行询问。

    Coherent spin valve and related devices
    5.
    发明申请
    Coherent spin valve and related devices 有权
    相干自旋阀及相关装置

    公开(公告)号：US20060183002A1

    公开(公告)日：2006-08-17

    申请号：US11241292

    申请日：2005-09-29

    Applicant: Haitao Yang ,  Xiao-Dong Xiang

    Inventor： Haitao Yang ,  Xiao-Dong Xiang

    IPC: G11B5/39

    CPC classification number: G06N99/002 ,  B82Y10/00 ,  B82Y25/00 ,  G11B5/3903 ,  H01F10/1936 ,  H01F10/3268 ,  H01F10/329 ,  Y10S977/933 ,  Y10T428/1107

    Abstract: Embodiments of the present invention are directed toward the field of spintronics, and in particular, systems and devices capable of performing spin coherent quantum logic operations. The inventive spin valve comprises two ferromagnetic electrode layers, and a non-magnetic conducting layer positioned therebetween. An external magnetic field {right arrow over (B)}0 is applied in the Z direction, such that the two electrode layers are each magnetized in a direction substantially parallel to the external magnetic field. Rather than attempting to change the magnetization of one of the ferromagnetic layers, as is the case in prior art technologies, it is the direction of the electron spin that is manipulated in the present embodiments while the electron is traveling through the middle, nonmagnetic layer. One of the ferromagnetic electrodes may be the tip of a scanning tunneling microscope (STM). This configuration may further comprise a bias voltage source connected between the STM tip and the other ferromagnetic electrode, such that a spin polarized tunneling current is conducted between the two.

    Abstract translation: 本发明的实施例涉及自旋电子学领域，特别是能够执行自相关量子逻辑运算的系统和装置。 本发明的自旋阀包括两个铁磁电极层和位于它们之间的非磁性导电层。 在Z方向上施加外部磁场（向右箭头（B 0 ），使得两个电极层各自在基本上平行于外部磁场的方向上磁化，而不是试图改变 如现有技术中的一种铁磁层的磁化，它是在电子行进通过中间非磁性层时在本实施例中操纵的电子自旋的方向，一个铁磁电极 可以是扫描隧道显微镜（STM）的尖端，该配置还可以包括连接在STM尖端和另一个铁磁电极之间的偏置电压源，使得在两者之间进行自旋极化隧道电流。

    Evanescent microwave probe with enhanced resolution and sensitivity
    7.
    发明申请
    Evanescent microwave probe with enhanced resolution and sensitivity 失效
    渐近微波探头具有更高的分辨率和灵敏度

    公开(公告)号：US20060125465A1

    公开(公告)日：2006-06-15

    申请号：US11180045

    申请日：2005-07-11

    Applicant: Xiao-Dong Xiang ,  Haitao Yang ,  Gang Wang

    Inventor： Xiao-Dong Xiang ,  Haitao Yang ,  Gang Wang

    IPC: G01R31/02

    CPC classification number: G01Q10/065 ,  G01Q60/22

    Abstract: Novel systems of an evanescent microwave probe (EWP) are disclosed, which enable measurements of physical properties of a sample with enhanced sensitivity and resolution, simultaneously. In one embodiment, new shielding features are added to the probe (which may be of either a sharpened tip or loop configuration) to reduce the effects of residual far field radiation, while maintaining the probe section that extends beyond the shielding aperture of the resonator. To further increase the sensitivity of the instrument, an automatic gain-controlled active feedback loop system may be added to the probe resonator to form a self-oscillator. This new active circuit feature significantly increases the effective Q of the resonator probe, enhancing the sensitivity of both the frequency and Q measurement.

    Abstract translation: 公开了一种ev逝微波探测器（EWP）的新型系统，可同时测量具有增强灵敏度和分辨率的样品的物理性能。 在一个实施例中，将新的屏蔽特征添加到探头（其可以是尖锐的尖端或环形配置）以减少残余远场辐射的影响，同时保持探头部分延伸超出谐振器的屏蔽孔径。 为了进一步提高仪器的灵敏度，可以将自动增益控制的主动反馈回路系统添加到探头谐振器中以形成自振荡器。 这种新的有源电路特征显着增加了谐振器探头的有效Q，提高了频率和Q测量的灵敏度。

    Coherent spin valve and related devices
    8.
    发明授权
    Coherent spin valve and related devices 失效
    相干自旋阀及相关装置

    公开(公告)号：US08049996B2

    公开(公告)日：2011-11-01

    申请号：US12236327

    申请日：2008-09-23

    Applicant: Haitao Yang ,  Xiao-Dong Xiang

    Inventor： Haitao Yang ,  Xiao-Dong Xiang

    IPC: G11B5/39 ,  H01L29/82

    CPC classification number: G06N99/002 ,  B82Y10/00 ,  B82Y25/00 ,  G11B5/3903 ,  H01F10/1936 ,  H01F10/3268 ,  H01F10/329 ,  Y10S977/933 ,  Y10T428/1107

    Abstract: Embodiments of the present invention are directed toward the field of spintronics, and in particular, systems and devices capable of performing spin coherent quantum logic operations. The inventive spin valve comprises two ferromagnetic electrode layers, and a non-magnetic conducting layer positioned therebetween. An external magnetic field B0 is applied in the Z direction, such that the two electrode layers are each magnetized in a direction substantially parallel to the external magnetic field. Rather than attempting to change the magnetization of one of the ferromagnetic layers, as is the case in prior art technologies, it is the direction of the electron spin that is manipulated in the present embodiments while the electron is traveling through the middle, nonmagnetic layer. One of the ferromagnetic electrodes may be the tip of a scanning tunneling microscope (STM). This configuration may further comprise a bias voltage source connected between the STM tip and the other ferromagnetic electrode, such that a spin polarized tunneling current is conducted between the two.

    Abstract translation: 本发明的实施例涉及自旋电子学领域，特别是能够执行自相关量子逻辑运算的系统和装置。 本发明的自旋阀包括两个铁磁电极层和位于它们之间的非磁性导电层。 在Z方向上施加外部磁场B0，使得两个电极层在大致平行于外部磁场的方向上各自被磁化。 与现有技术中的情况一样，不是试图改变铁磁层之一的磁化，而是在电子行进通过中间非磁性层时在本实施例中操纵的电子自旋的方向。 铁磁电极之一可以是扫描隧道显微镜（STM）的尖端。 该配置还可以包括连接在STM尖端和另一个铁磁电极之间的偏置电压源，使得在两者之间进行自旋极化隧穿电流。

    Detection with evanescent wave probe
    9.
    发明授权
    Detection with evanescent wave probe 失效
    用ev逝波探测器进行检测

    公开(公告)号：US07148683B2

    公开(公告)日：2006-12-12

    申请号：US10833186

    申请日：2004-04-28

    Applicant: Xiao Dong Xiang ,  Haitao Yang ,  Gang Wang

    Inventor： Xiao Dong Xiang ,  Haitao Yang ,  Gang Wang

    IPC: G01V3/00

    CPC classification number: G01R33/60 ,  G01N24/00 ,  G01N24/006 ,  G01N24/08 ,  G01N24/10 ,  G01R33/345

    Abstract: Methods and systems for spatially resolved spin resonance detection in a sample of material are disclosed. Also disclosed are methods and systems for spatially resolved impedance measurements in a sample of material. The disclosed methods and samples can be used in screening of plurality of biological, chemical and material samples.

    Abstract translation: 公开了用于材料样品中空间分辨的自旋共振检测的方法和系统。 还公开了用于材料样品中的空间分辨阻抗测量的方法和系统。 所公开的方法和样品可用于筛选多个生物，化学和物质样品。

    Integrated EWP-STM spin resonance microscope
    10.
    发明授权
    Integrated EWP-STM spin resonance microscope 失效
    综合EWP-STM自旋共振显微镜

    公开(公告)号：US07109706B2

    公开(公告)日：2006-09-19

    申请号：US11216931

    申请日：2005-08-30

    Applicant: Xiao-Dong Xiang ,  Haitao Yang

    Inventor： Xiao-Dong Xiang ,  Haitao Yang

    IPC: G01V3/00

    CPC classification number: G01R33/60 ,  G01N24/10 ,  G01Q30/02 ,  G01Q60/12 ,  G01R33/26 ,  G01R33/323 ,  G01R33/4808

    Abstract: A novel spin resonance microscope is disclosed, the microscope design comprising an integrated evanescent wave probe and scanning tunneling microscope tip. The probe and tip may be either the same structure, or they may be separate structures. The integrated design allows for coherent excitation of precessing electron spin states in the sample such that spin resonance may be detected because the tunneling current is modulated by the spin resonance. Spin resonance may be affected by either adjacent nuclei, or by adjacent electrons. The present apparatus requires significantly reduced power inputs, such that the dead time of the system is short, and relaxation phenomena may be evaluated without swamping the instrument's electronics.

    Abstract translation: 公开了一种新型的自旋共振显微镜，显微镜设计包括集成的ev逝波探针和扫描隧道显微镜尖端。 探针和尖端可以是相同的结构，或者它们可以是分离的结构。 该集成设计允许在样品中进行电子自旋状态的相干激发，使得可以检测自旋共振，因为隧道电流被自旋共振调制。 旋转共振可能受相邻核或相邻电子的影响。 本装置需要显着降低的功率输入，使得系统的死区时间短，并且可以评估松弛现象而不会使仪器的电子元件变形。

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