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    Recombinant human papillomavirus vaccine expressed in transgenic plants
    1.
    发明授权
    Recombinant human papillomavirus vaccine expressed in transgenic plants 有权
    在转基因植物中表达的重组人乳头瘤病毒疫苗

    公开(公告)号：US06444805B1

    公开(公告)日：2002-09-03

    申请号：US09512569

    申请日：2000-02-24

    Applicant: Ulk Sohn ,  Hong Gil Nam ,  Deok Hoon Park ,  Kuk Hyun Kim

    Inventor： Ulk Sohn ,  Hong Gil Nam ,  Deok Hoon Park ,  Kuk Hyun Kim

    IPC: C07H2104

    CPC classification number: C12N15/8258 ,  Y10S977/802

    Abstract: The oral vaccine of the present invention containing the HPV like particles is produced in edible transgenic plants and then administered through the consumption of the edible portion of those plants or after the purification of the particles. A DNA sequence encoding one of the HPV capsid proteins is isolated, inserted into the plasmid which comprises a plant-specific promoter and a gene for a selection marker, and then transferred to plant cells to give transgenic plants. Since the gene is expressed in a portion of the plants, the oral vaccine of the present invention can be produced in an inexpensive manner and administered in a simple method.

    Abstract translation: 含有HPV样颗粒的本发明的口服疫苗是在可食用的转基因植物中产生的，然后通过消耗那些植物的可食用部分或在颗粒纯化后施用。 分离编码HPV衣壳蛋白之一的DNA序列，插入包含植物特异性启动子和选择标记基因的质粒中，然后转移至植物细胞以产生转基因植物。 由于该基因在植物的一部分中表达，所以本发明的口服疫苗可以以便宜的方式制备并以简单的方法施用。

    Compositions for Improving Skin Conditions Comprising Alpha-Bisabolol as an Active Ingredient
    4.
    发明申请
    Compositions for Improving Skin Conditions Comprising Alpha-Bisabolol as an Active Ingredient 审中-公开
    用于改善包含α-对映体作为活性成分的皮肤状况的组合物

    公开(公告)号：US20100015071A1

    公开(公告)日：2010-01-21

    申请号：US12527756

    申请日：2008-02-27

    Applicant: Deok Hoon Park ,  Sae Bom Kim ,  Jong Sung Lee

    Inventor： Deok Hoon Park ,  Sae Bom Kim ,  Jong Sung Lee

    IPC: A61K8/34 ,  A61Q7/00 ,  A61Q17/04 ,  A61Q19/02

    CPC classification number: A61K8/34 ,  A23L33/105 ,  A61Q7/00 ,  A61Q17/04 ,  A61Q19/02 ,  A61Q19/08

    Abstract: The present invention relates to a composition for improving skin condition comprising α-bisabolol as an active ingredient. α-Bisabolol used as an active ingredient has greater skin whitening effect inhibiting melanin synthesis by inhibiting intracellular tyrosinase activities compared to arbutin used as an existing skin whitening agent. In addition, α-bisabolol exhibits the inhibition effect on collagenase activity and promotion effect on collagen biosynthesis at a molecular level, contributing to excellent efficacy in improvement of skin wrinkles. Meanwhile, α-bisabolol indicates the improvement effects on UV-induced skin damage and the skin growth promotion or hair loss prevention. Therefore, α-bisabolol has the excellent improvement effects on skin condition. Furthermore, α-bisabolol has the excellent anti-obesity and anti-oxidation effects. The composition of this invention can be applied to cosmetic, pharmaceutical and food composition having no cytotoxicities and side effects with safety.

    Abstract translation: 本发明涉及一种用于改善皮肤状况的组合物，其包含α-红布罗尔作为活性成分。 与用作现有皮肤增白剂的熊果苷相比，用作活性成分的α-红假单松醇通过抑制细胞内酪氨酸酶活性而具有更大的皮肤美白效果，抑制黑色素合成。 另外，α-红没药醇在分子水平上表现出对胶原酶活性的抑制作用和对胶原生物合成的促进作用，有助于提高皮肤皱纹的优异疗效。 同时，阿拉伯红参还表明对紫外线诱导的皮肤损伤和皮肤生长促进或减少脱发的改善作用。 因此，阿拉伯半宝兰对皮肤状况有极好的改善作用。 此外，α-红没药醇具有优异的抗肥胖和抗氧化作用。 本发明的组合物可以应用于无细胞毒性和安全性的副作用的化妆品，药​​物和食品组合物。

    Method for increasing content of physiologically active substance in ginseng
    5.
    发明申请
    Method for increasing content of physiologically active substance in ginseng 审中-公开
    提高人参生理活性物质含量的方法

    公开(公告)号：US20070224297A1

    公开(公告)日：2007-09-27

    申请号：US11725885

    申请日：2007-03-20

    Applicant: Deok Hoon Park ,  Jong Sung Lee ,  Eunsun Jung

    Inventor： Deok Hoon Park ,  Jong Sung Lee ,  Eunsun Jung

    IPC: A61K36/258 ,  A61K8/97

    CPC classification number: A61K36/258 ,  A61K8/97 ,  A61Q19/08

    Abstract: The present invention relates to a method for economically preparing ginseng extract having an increased content of physiologically active substances, comprising the steps of steaming ginseng at 95 to 100° C. for 1 to 24 hours, collecting the generated vapor by cooling, and repeating the process twice, to a composition for promoting collagen synthesis, comprising the extract, and to a cosmetic product for improving skin wrinkles, comprising the composition.

    Abstract translation: 本发明涉及一种经济地制备具有增加的生理活性物质含量的人参提取物的方法，包括以下步骤：在95至100℃蒸汽1至24小时，通过冷却收集产生的蒸气，并重复 处理两次，用于促进胶原蛋白合成的组合物，其包含提取物，以及用于改善皮肤皱纹的化妆品，其包含该组合物。

    Compositions for Improving Skin Conditions Comprising Matrine or Its Oxidized Derivatives
    7.
    发明申请
    Compositions for Improving Skin Conditions Comprising Matrine or Its Oxidized Derivatives 审中-公开
    用于改善包括苦参碱或其氧化衍生物的皮肤病症的组合物

    公开(公告)号：US20100099698A1

    公开(公告)日：2010-04-22

    申请号：US12527237

    申请日：2008-02-21

    Applicant: Deok Hoon Park ,  Eun Sun Jung ,  Jong Sung Lee

    Inventor： Deok Hoon Park ,  Eun Sun Jung ,  Jong Sung Lee

    IPC: A61K8/49 ,  A61Q19/00

    CPC classification number: A61K8/4926 ,  A61K2800/522 ,  A61K2800/782 ,  A61Q7/00 ,  A61Q17/04 ,  A61Q19/02 ,  A61Q19/08

    Abstract: The present invention relates to a composition for improving skin conditions comprising matrine and oxymatrine as an active ingredient. Matrine and oxymatrine have lower cytotoxicity than retinol used as anti-wrinkle agents and exhibit the inhibition effect on collagenase activity and promotion effect on collagen biosynthesis at a molecular level, contributing to excellent efficacy in improvement of skin wrinkles. In addition, both matrine and oxymatrine exhibit the inhibition effect on melanin production by inhibiting intracellular tyrosinase activity, the improving effects of UV-induced skin damage and the skin growth promotion or hair loss prevention. Therefore, matrine and oxymatrine have the excellent improvement effects on skin conditions. Furthermore, matrine and oxymatrine have the excellent anti-obesity and anti-oxidation effects. The composition of this invention can be applied to cosmetic, pharmaceutical and food composition having no cytotoxicities and side effects.

    Abstract translation: 本发明涉及一种用于改善皮肤病症的组合物，其包含苦参碱和氧化苦参碱作为活性成分。 苦参碱和氧化苦参碱比用作抗皱剂的视黄醇具有更低的细胞毒性，并且在分子水平上表现出对胶原酶活性的抑制作用和对胶原生物合成的促进作用，有助于提高皮肤皱纹的优异疗效。 此外，苦参碱和氧化苦参碱都通过抑制细胞内酪氨酸酶活性，改善UV诱导的皮肤损伤和皮肤生长促进或减少脱发的效果来显示对黑色素产生的抑制作用。 因此，苦参碱和氧化苦参碱对皮肤状况有极好的改善作用。 此外，苦参碱和氧化苦参碱具有优异的抗肥胖和抗氧化作用。 本发明的组合物可以应用于没有细胞毒性和副作用的化妆品，药​​物和食品组合物。

    Composition Comprising Vegetable Peptone for Promoting Stem Cell Proliferation
    9.
    发明申请
    Composition Comprising Vegetable Peptone for Promoting Stem Cell Proliferation 审中-公开
    包含蔬菜蛋白胨促成干细胞增殖的组合物

    公开(公告)号：US20110028404A1

    公开(公告)日：2011-02-03

    申请号：US12936055

    申请日：2009-03-19

    Applicant: Deok Hoon Park ,  Jienny Lee ,  Jong Sung Lee

    Inventor： Deok Hoon Park ,  Jienny Lee ,  Jong Sung Lee

    IPC: A61K38/16 ,  A61K8/64 ,  A61P17/00 ,  A61Q19/08

    CPC classification number: C12N5/0018 ,  A61K8/645 ,  A61Q19/08 ,  C12N2500/76

    Abstract: The present invention relates to a composition for promoting stem cell proliferation which contains a vegetable peptone. More specifically, this invention relates to: a serum-free composition for culturing stem cells which contains a vegetable peptone; a composition for improving skin condition containing the vegetable peptone as an active ingredient; and a composition for improving skin condition containing a culture medium as an active ingredient in which cultured stem cells are removed after being cultured in a serum-free composition medium for stem cell culture containing the vegetable peptone. Since the disclosed serum-free composition for culturing stem cells does not need the use of expensive animal serum, the manufacturing cost can be remarkably lowered. Also the use of anima serum in the medium can basically prevent contamination material caused by the use of animal serum. In addition, the disclosed composition containing the vegetable peptone and the medium in which the stem cells are cultured in the serum-free medium both serve to promote and activated the proliferation of stem cells, and improve various skin conditions.

    Abstract translation: 本发明涉及含有植物蛋白胨的促进干细胞增殖的组合物。 更具体地，本发明涉及：含有植物蛋白胨的培养干细胞的无血清组合物; 用于改善含有植物蛋白胨作为活性成分的皮肤状态的组合物; 以及含有培养基作为活性成分的皮肤状态改善组合物，其中在含有植物蛋白胨的干细胞培养物的无血清组合培养基中培养后，除去培养的干细胞。 由于公开的用于培养干细胞的无血清组合物不需要使用昂贵的动物血清，所以制造成本可以显着降低。 此外，在培养基中使用动脉血清可以基本上防止使用动物血清引起的污染物质。 此外，所公开的含有植物蛋白胨的组合物和干细胞在无血清培养基中培养的培养基均用于促进和激活干细胞的增殖，并改善各种皮肤状况。

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