公开(公告)号：US12188914B2

公开(公告)日：2025-01-07

申请号：US17659980

申请日：2022-04-20

Applicant: Trace Sensing Technologies Inc.

Inventor： Peter P. Ricci ,  Otto J. Gregory

IPC: G01N33/00 ,  G01K17/06 ,  G01N27/12 ,  G01N27/14

Abstract: Ultrasensitive, decoupled thermodynamic sensing platforms for the molecular-level detection of target analytes are disclosed, wherein the sensors have a heating resistor decoupled from a sensing resistor. Embodiments of the decoupled sensor comprise a metallic microheater resistor on one side of substrate, and a sensor resistor coupled to a catalyst on the other side of the substrate. A sensor array may be provided including a plurality of sensors each having a different catalyst that, when exposed to an analyte, each experience an endothermic reaction, an exothermic reaction, or no reaction. A comparison of the reaction results to data comprising previously obtained reaction results may be used to determine the presence and the identity of the analyte. Advantageously, the decoupled sensors utilize less power and provide greater sensitivity than other-known systems, and may be used to detect and identify a single molecule of an analyte.