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公开(公告)号：US10981867B2
公开(公告)日：2021-04-20
申请号：US16571896
申请日：2019-09-16
发明人： Troy E. Messick , Garry R. Smith , Allen B. Reitz , Paul M. Lieberman , Mark E. McDonnell , Yan Zhang , Marianne Carlsen , Shuai Chen
IPC分类号： C07D209/08 , C07D403/12 , C07D405/14 , C07D401/12 , C07D405/12 , C07D409/12 , C07D487/08 , C07D471/08 , C07D417/12 , A61P35/00 , A61P31/20 , A61K31/404 , A61K31/41 , A61K31/4155 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/435 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , C07D277/62 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/10 , C07D417/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
摘要： The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.
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公开(公告)号：US20240246909A1
公开(公告)日：2024-07-25
申请号：US18408389
申请日：2024-01-09
发明人： Troy E. Messick , Garry R. Smith , Allen B. Reitz , Paul M. Lieberman , Mark E. McDonnell , Yan Zhang , Marianne Carlsen , Shuai Chen
IPC分类号： C07D209/08 , A61K31/404 , A61K31/41 , A61K31/4155 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/435 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , A61P31/20 , A61P35/00 , C07D277/62 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D417/10 , C07D417/12 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/107
CPC分类号： C07D209/08 , A61K31/404 , A61K31/41 , A61K31/4155 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/435 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , A61P31/20 , A61P35/00 , C07D277/62 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D417/10 , C07D417/12 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/107
摘要： The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.
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公开(公告)号：US10442763B2
公开(公告)日：2019-10-15
申请号：US15571223
申请日：2016-05-14
发明人： Troy E. Messick , Garry R. Smith , Allen B. Reitz , Paul M. Lieberman , Mark E. McDonnell , Yan Zhang , Marianne Carlsen , Shuai Chen
IPC分类号： C07D209/08 , C07D403/12 , C07D405/14 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/08 , C07D487/08 , A61P35/00 , A61P31/20 , A61K31/404 , A61K31/41 , A61K31/4155 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/435 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , C07D277/62 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/10 , C07D417/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
摘要： The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.
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公开(公告)号：US11912659B2
公开(公告)日：2024-02-27
申请号：US17232511
申请日：2021-04-16
发明人： Troy E. Messick , Garry R. Smith , Allen B. Reitz , Paul M. Lieberman , Mark E. McDonnell , Yan Zhang , Marianne Carlsen , Shuai Chen
IPC分类号： C07D209/08 , C07D403/12 , C07D405/14 , C07D401/12 , C07D405/12 , C07D409/12 , C07D487/08 , C07D471/08 , C07D417/12 , A61P35/00 , A61P31/20 , A61K31/404 , A61K31/41 , A61K31/4155 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/435 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , C07D277/62 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/10 , C07D417/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
CPC分类号： C07D209/08 , A61K31/404 , A61K31/41 , A61K31/4155 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/435 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , A61P31/20 , A61P35/00 , C07D277/62 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D417/10 , C07D417/12 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/107
摘要： The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.
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公开(公告)号：US20200239415A1
公开(公告)日：2020-07-30
申请号：US16571896
申请日：2019-09-16
发明人： Troy E. Messick , Garry R. Smith , Allen B. Reitz , Paul M. Lieberman , Mark E. McDonnell , Yan Zhang , Marianne Carlsen , Shuai Chen
IPC分类号： C07D209/08 , A61K31/422 , C07D401/10 , C07D471/04 , A61K31/541 , A61K31/437 , A61K31/41 , A61K31/501 , A61K31/427 , C07D403/14 , C07D277/62 , A61K31/4155 , A61K31/519 , C07D417/10 , A61K31/551 , A61K31/496 , C07D403/12 , A61K31/4375 , C07D401/12 , C07D413/10 , A61K45/06 , A61K31/4725 , C07D417/12 , C07D491/107 , A61K31/4439 , C07D403/10 , C07D401/14 , C07D487/04 , A61K31/435 , A61K31/404 , A61K31/5377 , A61K31/506 , A61K31/454 , A61P35/00 , C07D471/08 , A61K31/517 , C07D471/10 , A61P31/20 , A61K31/433 , C07D409/12 , C07D487/08 , A61K31/426 , C07D405/12 , C07D405/14
摘要： The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.
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公开(公告)号：US20180305312A1
公开(公告)日：2018-10-25
申请号：US15571223
申请日：2016-05-14
发明人： Troy E. Messick , Garry R. Smith , Allen B. Reitz , Paul M. Lieberman , Mark E. McDonnell , Yan Zhang , Marianne Carlsen , Shuai Chen
IPC分类号： C07D209/08 , A61K31/5377 , C07D405/12 , A61K31/404 , C07D471/04 , A61K31/437 , A61K31/541 , A61K31/4375 , C07D405/14 , A61K31/454 , C07D401/14 , C07D409/12 , A61K31/496 , C07D403/10 , A61K31/41 , C07D413/10 , A61K31/422 , A61K31/501 , C07D401/10 , A61K31/4725 , C07D403/14 , C07D401/12 , A61K31/4439 , C07D403/12 , A61K31/506 , A61K31/4155 , C07D277/62 , A61K31/426 , C07D491/107 , A61K31/435 , C07D417/10 , A61K31/427 , A61K31/433 , A61K31/517 , A61K31/519 , A61K31/551 , C07D487/04 , C07D471/10 , A61K45/06 , A61P31/20
CPC分类号： C07D209/08 , A61K31/404 , A61K31/41 , A61K31/4155 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/435 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , A61P31/20 , A61P35/00 , C07D277/62 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D417/10 , C07D417/12 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/107
摘要： The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.
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公开(公告)号：US20220064112A1
公开(公告)日：2022-03-03
申请号：US17232511
申请日：2021-04-16
发明人： Troy E. Messick , Garry R. Smith , Allen B. Reitz , Paul M. Lieberman , Mark E. McDonnell , Yan Zhang , Marianne Carlsen , Shuai Chen
IPC分类号： C07D209/08 , C07D403/12 , C07D405/14 , C07D401/12 , C07D405/12 , C07D409/12 , C07D487/08 , C07D471/08 , C07D417/12 , A61P35/00 , A61P31/20 , A61K31/404 , A61K31/41 , A61K31/4155 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/435 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , C07D277/62 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/10 , C07D417/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
摘要： The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.
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