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    DELIVERY OF IBUPROFEN AND OTHER COMPOUNDS
    4.
    发明申请
    DELIVERY OF IBUPROFEN AND OTHER COMPOUNDS 有权
    交付IBUPROFEN和其他化合物

    公开(公告)号：US20150366829A1

    公开(公告)日：2015-12-24

    申请号：US14841767

    申请日：2015-09-01

    Applicant: Strategic Science & Technologies, LLC

    Inventor： Eric T. Fossel

    IPC: A61K31/192 ,  A61K47/36 ,  A61K47/12 ,  A61K47/26 ,  A61K47/02 ,  A61K9/00 ,  A61K47/10

    CPC classification number: A61K47/36 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/107 ,  A61K9/127 ,  A61K9/7023 ,  A61K31/192 ,  A61K31/522 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26

    Abstract: The present invention generally relates to the transdermal delivery of various compositions. In some aspects, the transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising ibuprofen and/or an ibuprofen salt, a nitric oxide donor, and optionally, a hostile biophysical environment. In some cases, the composition may be stabilized using a stabilization polymer such as xanthan gum, KELTROL® BT and/or KELTROL® RD; propylene glycol; and a polysorbate surfactant such as Polysorbate 20, which unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.

    Abstract translation: 本发明一般涉及各种组合物的透皮递送。 在一些方面，可以通过使用敌对的生物物理环境来促进透皮递送。 一组实施方案提供用于局部递送的组合物，其包含布洛芬和/或布洛芬盐，一氧化氮供体和任选的敌对生物物理环境。 在一些情况下，组合物可以使用稳定化聚合物例如黄原胶，TREL和/或RDEL来稳定; 丙二醇 和聚山梨醇酯表面活性剂如聚山梨醇酯20，其意外地为组合物提供温度稳定性，例如在高温下，例如至少40℃（至少约104°F），与不含一种或多种 这些。

    BENEFICIAL EFFECTS OF INCREASING LOCAL BLOOD FLOW
    6.
    发明申请
    BENEFICIAL EFFECTS OF INCREASING LOCAL BLOOD FLOW 有权
    增加当地血液流量的有益效果

    公开(公告)号：US20130289059A1

    公开(公告)日：2013-10-31

    申请号：US13860070

    申请日：2013-04-10

    Applicant: Strategic Science & Technologies, LLC

    Inventor： Eric T. Fossel

    IPC: A61K31/198 ,  A61K45/06 ,  A61K31/223

    CPC classification number: A61K31/198 ,  A61K31/223 ,  A61K45/06 ,  A61K2300/00

    Abstract: The present invention generally relates to the improvement of tissue health by increasing local blood flow. In some aspects of the invention, increased local blood flow is effected by the transdermal delivery of the nitric oxide precursor L-arginine and/or its derivatives alone, or optionally in conjunction with an adjunct such as theophylline. The transdermal delivery is effected, in certain embodiments through the means of a hostile biophysical environment, such as that created by a high ionic strength environment. Various pathological states caused by, or occurring in conjunction with, insufficient blood flow, can be treated using the systems and methods of the invention as described herein. In other embodiments, increased blood flow using the systems and methods of the invention may result in enhanced healing, for example, through greater availability of the constituents of the blood. Examples of conditions which may benefit from increased blood flow include, but are not limited to, erectile dysfunction, hair loss, female sexual dissatisfaction, sagging facial or other body tissue, peripheral vascular disease including claudication, neuropathy, skin ulcers, bone healing, wound healing, viral and bacterial infection, and skin grafting.

    Abstract translation: 本发明一般涉及通过增加局部血流量来改善组织健康。 在本发明的一些方面，通过一氧化氮前体L-精氨酸和/或其衍生物单独的透皮递送或任选地与辅助物例如茶碱结合来实现增加的局部血流量。 在某些实施方案中，通过敌对生物物理环境（例如由高离子强度环境产生的环境）的手段实现透皮递送。 可以使用如本文所述的本发明的系统和方法来治疗由或不足的血流引起的或与其结合的各种病理状态。 在其他实施方案中，使用本发明的系统和方法增加的血液流量可以导致增强的愈合，例如，通过更多的血液成分的可用性。 可能受益于血流增加的病症的实例包括但不限于勃起功能障碍，脱发，女性性不满，下垂面部或其他身体组织，外周血管疾病，包括跛行，神经病，皮肤溃疡，骨愈合，伤口 愈合，病毒和细菌感染以及皮肤移植。

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