公开(公告)号：US12122817B2

公开(公告)日：2024-10-22

申请号：US17184248

申请日：2021-02-24

Applicant: Serpentide Inc.

Inventor： Yang Wei

IPC: A61K38/26 ,  A61K39/395 ,  A61K45/06 ,  A61P3/10 ,  C07K14/605 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K14/605 ,  A61K38/26 ,  A61K39/3955 ,  A61K45/06 ,  A61P3/10 ,  C07K16/28 ,  C07K16/2869 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2319/30 ,  C07K2319/35 ,  C07K2319/50

Abstract: Modified glucagon-like peptide (GLP1) fusion proteins with modified GLP1 polypeptides and related methods of use are described. Aspects of the disclosure further relate to fusion proteins that are GLP1 receptor agonists with a modified GLP1 fused to a stabilizing domain such as an extra cellular domain or antibody. Fusion proteins with modified GLP1 that are useful for treating or ameliorating a symptom or indication of a blood sugar disorder such as obesity and diabetes are also provided.