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公开(公告)号：US20230277726A1
公开(公告)日：2023-09-07
申请号：US18113449
申请日：2023-02-23
Applicant: SERNOVA CORP.
Inventor： Jeffrey Hubbell , Alice Tomei
IPC: A61L27/34 , A61K47/10 , C12N5/00 , A61K9/00 , A61K9/06 , A61K9/48 , A61K9/20 , A61K35/39 , A61L27/36
CPC classification number: A61L27/34 , A61K47/10 , C12N5/0012 , A61K9/0024 , A61K9/06 , A61K9/4858 , A61K9/2059 , A61K9/008 , A61K9/2027 , A61K9/2054 , A61K9/0019 , A61K9/2018 , A61K9/4866 , A61K35/39 , A61L27/3604 , A61L27/3683 , A61L2420/02
Abstract: Hydrodynamic methods for conformally coating non-uniform size cells and cell clusters for implantation, thus preventing immune rejection or inflammation or autoimmune destruction while preserving cell functionality. A method for conformally coating cells and c clusters with hydrogels that are biocompatible, mechanically and chemically stable and porous, with an appropriate pore cut-off size. The methods of the invention are advantageously reproducible and result in a relatively high yield of coated versus non-coated cell clusters, without compromising cell functionality. Conformal coating devices configured to perform the methods of the invention, methods of optimally utilizing said devices and purifying the coated islets, and coated biomaterials made by said methods.
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公开(公告)号：US20220125992A1
公开(公告)日：2022-04-28
申请号：US17528442
申请日：2021-11-17
Applicant: SERNOVA CORP.
Inventor： Jeffrey Hubbell , Alice Tomei
IPC: A61L27/34 , A61K47/10 , C12N5/00 , A61K9/00 , A61K9/06 , A61K9/48 , A61K9/20 , A61K35/39 , A61L27/36
Abstract: Hydrodynamic methods for conformally coating non-uniform size cells and cell clusters for implantation, thus preventing immune rejection or inflammation or autoimmune destruction while preserving cell functionality. A method for conformally coating cells and c clusters with hydrogels that are biocompatible, mechanically and chemically stable and porous, with an appropriate pore cut-off size. The methods of the invention are advantageously reproducible and result in a relatively high yield of coated versus non-coated cell clusters, without compromising cell functionality. Conformal coating devices configured to perform the methods of the invention, methods of optimally utilizing said devices and purifying the coated islets, and coated biomaterials made by said methods.
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公开(公告)号：US11207444B2
公开(公告)日：2021-12-28
申请号：US16847220
申请日：2020-04-13
Applicant: SERNOVA CORP.
Inventor： Jeffrey Hubbell , Alice Tomei
IPC: A61L27/34 , A61K47/10 , C12N5/00 , A61K9/00 , A61K9/06 , A61K9/48 , A61K9/20 , A61K35/39 , A61L27/36
Abstract: Hydrodynamic methods for conformally coating non-uniform size cells and cell clusters for implantation, thus preventing immune rejection or inflammation or autoimmune destruction while preserving cell functionality. A method for conformally coating cells and c clusters with hydrogels that are biocompatible, mechanically and chemically stable and porous, with an appropriate pore cut-off size. The methods of the invention are advantageously reproducible and result in a relatively high yield of coated versus non-coated cell clusters, without compromising cell functionality. Conformal coating devices configured to perform the methods of the invention, methods of optimally utilizing said devices and purifying the coated islets, and coated biomaterials made by said methods.
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公开(公告)号：US11623021B2
公开(公告)日：2023-04-11
申请号：US17528442
申请日：2021-11-17
Applicant: SERNOVA CORP.
Inventor： Jeffrey Hubbell , Alice Tomei
IPC: A61L27/34 , A61K47/10 , C12N5/00 , A61K9/00 , A61K9/06 , A61K9/48 , A61K9/20 , A61K35/39 , A61L27/36
Abstract: Hydrodynamic methods for conformally coating non-uniform size cells and cell clusters for implantation, thus preventing immune rejection or inflammation or autoimmune destruction while preserving cell functionality. A method for conformally coating cells and c clusters with hydrogels that are biocompatible, mechanically and chemically stable and porous, with an appropriate pore cut-off size. The methods of the invention are advantageously reproducible and result in a relatively high yield of coated versus non-coated cell clusters, without compromising cell functionality. Conformal coating devices configured to perform the methods of the invention, methods of optimally utilizing said devices and purifying the coated islets, and coated biomaterials made by said methods.
