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公开(公告)号：US10308684B2
公开(公告)日：2019-06-04
申请号：US15529967
申请日：2015-11-27
Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
Inventor： Jaehoon Yu , Soonsil Hyun , Yan Lee , Seonju Lee
IPC: A61K38/10 , A61K38/16 , A61K38/00 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K7/08 , A61K47/42 , A61K47/64 , A61K31/713 , C07K1/107 , C12N15/113 , C07K1/113 , C07K14/00 , A61K38/12
Abstract: The present invention relates to a stapled peptide, a preparation method thereof and the use thereof, and more specifically to an amphipathic alpha-helical stapled peptide comprising hydrophobic amino acids and hydrophilic amino acids, a preparation method thereof, and the use thereof for intracellular delivery of an active substance.
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公开(公告)号：US11123400B2
公开(公告)日：2021-09-21
申请号：US15761089
申请日：2016-09-19
Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
Inventor： Jaehoon Yu , Yan Lee , Soonsil Hyun , Seo Yeon Kim , Sun Mi Jin , Yunhwa Choi , Doyeon Jo , Seonju Lee
IPC: A61K38/10 , A01N37/18 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K38/16 , C07K7/08 , A61K31/616 , A61K31/431 , A61K31/192 , A61K31/05 , A61K31/12 , A61K31/5377 , A61K31/366 , A61P31/04 , A61P29/00 , A61P9/00 , A61K38/06 , A61K38/00 , A61K47/64
Abstract: The present invention relates to a broken or kinked helical peptide or peptide analogue and the use thereof, and more particularly to a Gram-negative bacterial membrane-penetrating peptide or peptide analogue wherein an alpha-helical amphipathic peptide composed of hydrophobic amino acids and hydrophilic amino acids has a kinked structure, or an antimicrobial composition employing the specific activity of the peptide against the Gram-negative bacterial membrane, or an antimicrobial composition for co-administration, or a conjugate comprising a drug linked to the peptide or peptide analogue, or an antibiotic comprising the same.
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公开(公告)号：US20170342108A1
公开(公告)日：2017-11-30
申请号：US15529967
申请日：2015-11-27
Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
Inventor： Jaehoon Yu , Soonsil Hyun , Yan Lee , Seonju Lee
IPC: C07K7/08 , A61K47/42 , C12N15/113 , A61K47/64 , C07K1/107 , A61K31/713
CPC classification number: C07K7/08 , A61K31/713 , A61K38/12 , A61K47/42 , A61K47/64 , A61K47/6455 , C07K1/1075 , C07K1/1077 , C07K1/113 , C07K14/001 , C12N15/113 , C12N2310/14 , C12N2320/32
Abstract: The present invention relates to a stapled peptide, a preparation method thereof and the use thereof, and more specifically to an amphipathic alpha-helical stapled peptide comprising hydrophobic amino acids and hydrophilic amino acids, a preparation method thereof, and the use thereof for intracellular delivery of an active substance.
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公开(公告)号：US20180339016A1
公开(公告)日：2018-11-29
申请号：US15761089
申请日：2016-09-19
Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
Inventor： Jaehoon Yu , Yan Lee , Soonsil Hyun , Seo Yeon Kim , Sun Mi Jin , Yunhwa Choi , Doyeon Jo , Seonju Lee
Abstract: The present invention relates to a broken or kinked helical peptide or peptide analogue and the use thereof, and more particularly to a Gram-negative bacterial membrane-penetrating peptide or peptide analogue wherein an alpha-helical amphipathic peptide composed of hydrophobic amino acids and hydrophilic amino acids has a kinked structure, or an antimicrobial composition employing the specific activity of the peptide against the Gram-negative bacterial membrane, or an antimicrobial composition for co-administration, or a conjugate comprising a drug linked to the peptide or peptide analogue, or an antibiotic comprising the same.
