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公开(公告)号：US20200032348A1
公开(公告)日：2020-01-30
申请号：US16491182
申请日：2018-03-09
Applicant: SELF-SCREEN B.V.
Inventor： Christophorus Joannes Lambertus Maria MEIJER , Renske Daniëla Maria STEENBERGEN , Petrus Josephus Ferdinandus SNIJDERS , Daniëlle Anne Marie HEIDEMAN
IPC: C12Q1/6886
Abstract: The invention relates to method for detecting HPV-induced high-grade precancerous lesions, HPV-induced invasive cancers and nonHPV-induced gynaecological and anogenital cancers, said method comprising detection of a methylation classifier consisting of the genes LHX8, ASCL1 and ST6GALNAC5 and their regulatory sequence in a cell whereby such hypermethylation indicates the presence of HPV-induced precursor lesions with invasive potential, HPV-induced invasive cancers and nonHPV-induced gynaecological and anogenital cancers. The invention further comprises the use of the methylation classifier consisting of genes LHX8, ASCL1 and ST6GALNAC5 and their regulatory sequence in such a method and a test kit for the detection of LHX8. ASCL1 and/or ST6GALNAC5 methylation.
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公开(公告)号：US20240336974A1
公开(公告)日：2024-10-10
申请号：US18430518
申请日：2024-02-01
Applicant: SELF-SCREEN B.V.
Inventor： Christophorus Joannes Lambertus Maria MEIJER , Renske Daniëla Maria STEENBERGEN , Petrus Josephus Ferdinandus SNIJDERS , Daniëlle Anne Marie HEIDEMAN
IPC: C12Q1/6886
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/154
Abstract: The invention relates to method for detecting HPV-induced high-grade precancerous lesions, HPV-induced invasive cancers and nonHPV-induced gynaecological and anogenital cancers, said method comprising detection of a methylation classifier consisting of the genes LHX8, ASCL1 and ST6GALNAC5 and their regulatory sequence in a cell whereby such hypermethylation indicates the presence of HPV-induced precursor lesions with invasive potential, HPV-induced invasive cancers and nonHPV-induced gynaecological and anogenital cancers. The invention further comprises the use of the methylation classifier consisting of genes LHX8, ASCL1 and ST6GALNAC5 and their regulatory sequence in such a method and a test kit for the detection of LHX8, ASCL1 and/or ST6GALNAC5 methylation.
