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公开(公告)号：US20180244787A1
公开(公告)日：2018-08-30
申请号：US15851651
申请日：2017-12-21
Applicant: SANOFI , UNIVERSITY OF MASSACHUSETTS
Inventor： William H. Brondyk , Ruiyin Chu , Timothy D. Connors , Sunghae Park , Huawei Qiu , Michele Youd , John Harris , Jillian Richmond
CPC classification number: C07K16/2866 , A61K2039/505 , A61P17/00 , A61P37/00 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94
Abstract: Provided are methods and uses of anti-CXCR3 antibodies to treat CXCR3-associated disorders such as vitiligo. In certain embodiments, the anti-CXCR3 antibodies are humanized anti-human CXCR3 antibodies with enhanced effector function against cells expressing CXCR3 on their surface.
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公开(公告)号：US20180214542A1
公开(公告)日：2018-08-02
申请号：US15851621
申请日：2017-12-21
Applicant: SANOFI
Inventor： William H. Brondyk , Ruiyin Chu , Timothy D. Connors , Sunghae Park , Huawei Qiu , Michele Youd
IPC: A61K39/395 , A61K38/19 , A61P3/10 , A61P17/06
CPC classification number: A61K39/395 , A61K38/195 , A61K2039/505 , A61P3/10 , A61P17/06 , A61P37/06 , C07K16/2866 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
Abstract: Provided are humanized CXCR3 antibodies and methods of using the antibodies to treat CXCR3-associated disorders such as type 1 diabetes mellitus (T1D), particularly new-onset T1D, and psoriasis. In certain embodiments, the anti-CXCR3 antibodies are humanized anti-human CXCR3 antibodies with enhanced effector function against cells expressing CXCR3 on their surface. Also provided are nucleic acid sequences encoding the antibodies, and pharmaceutical compositions comprising the antibodies.
